Title |
The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue
|
---|---|
Published in |
Cellular & Molecular Biology Letters, April 2014
|
DOI | 10.2478/s11658-014-0193-5 |
Pubmed ID | |
Authors |
Vladimir Potkin, Dzmitry Shcharbin, Andrey Denisov, Svetlana Paschkevich, Maria Bryszewska, Sergey Petkevich, Alexey Kletskov, Dmitri Lapotko, Vladimir Kazbanov, Tatiana Gurinovich, Vladimir Kulchitsky |
Abstract |
We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds - 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid - to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 42% |
Student > Master | 2 | 17% |
Other | 1 | 8% |
Student > Ph. D. Student | 1 | 8% |
Unknown | 3 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 25% |
Neuroscience | 2 | 17% |
Physics and Astronomy | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Chemistry | 1 | 8% |
Other | 0 | 0% |
Unknown | 4 | 33% |