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Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing Bcl-2 overexpression

Overview of attention for article published in Breast Cancer Research, February 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)

Mentioned by

twitter
2 tweeters
patent
1 patent
facebook
2 Facebook pages

Citations

dimensions_citation
51 Dimensions

Readers on

mendeley
52 Mendeley
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Title
Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing Bcl-2 overexpression
Published in
Breast Cancer Research, February 2015
DOI 10.1186/s13058-015-0533-z
Pubmed ID
Authors

Paromita Raha, Scott Thomas, K Ted Thurn, Jeenah Park, Pamela N Munster

Abstract

The emergence of hormone therapy resistance, despite continued expression of the estrogen receptor (ER), is a major challenge to curing breast cancer. Recent clinical studies suggest that epigenetic modulation by histone deacetylase (HDAC) inhibitors reverses hormone therapy resistance. However, little is known about epigenetic modulation of the ER during acquired hormone resistance. Our recent phase II study demonstrated that HDAC inhibitors re-sensitize hormone therapy resistant tumors to the anti-estrogen tamoxifen. In this study, we sought to understand the mechanism behind the efficacy of this combination.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 27%
Student > Ph. D. Student 10 19%
Student > Bachelor 8 15%
Researcher 6 12%
Lecturer 2 4%
Other 5 10%
Unknown 7 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 23%
Biochemistry, Genetics and Molecular Biology 11 21%
Medicine and Dentistry 9 17%
Pharmacology, Toxicology and Pharmaceutical Science 4 8%
Chemistry 3 6%
Other 6 12%
Unknown 7 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2017.
All research outputs
#4,587,384
of 17,359,532 outputs
Outputs from Breast Cancer Research
#625
of 1,706 outputs
Outputs of similar age
#56,903
of 221,752 outputs
Outputs of similar age from Breast Cancer Research
#1
of 1 outputs
Altmetric has tracked 17,359,532 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,706 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,752 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them