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Systemic lipopolysaccharide-mediated alteration of cortical neuromodulation involves increases in monoamine oxidase-A and acetylcholinesterase activity

Overview of attention for article published in Journal of Neuroinflammation, February 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)

Mentioned by

twitter
2 tweeters

Citations

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31 Dimensions

Readers on

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30 Mendeley
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Title
Systemic lipopolysaccharide-mediated alteration of cortical neuromodulation involves increases in monoamine oxidase-A and acetylcholinesterase activity
Published in
Journal of Neuroinflammation, February 2015
DOI 10.1186/s12974-015-0259-y
Pubmed ID
Authors

Zhi Ming, Caitlin A Wotton, Robert T Appleton, John C Ching, Matthew E Loewen, Grzegorz Sawicki, Lane K Bekar

Abstract

Lipopolysaccharide (LPS)-mediated sickness behaviour is known to be a result of increased inflammatory cytokines in the brain. Inflammatory cytokines have been shown to mediate increases in brain excitation by loss of GABAA-mediated inhibition through receptor internalization or inactivation. Inflammatory pathways, reactive oxygen species and stress are also known to increase monoamine oxidase-A (MAO-A) and acetylcholinesterase (ACh-E) activity. Given that neuromodulator actions on neural circuits largely depend on inhibitory pathways and are sensitive to alteration in corresponding catalytic enzyme activities, we assessed the impact of systemic LPS on neuromodulator-mediated shaping of a simple cortical network.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 40%
Student > Master 4 13%
Student > Bachelor 3 10%
Researcher 3 10%
Professor > Associate Professor 2 7%
Other 3 10%
Unknown 3 10%
Readers by discipline Count As %
Neuroscience 8 27%
Agricultural and Biological Sciences 5 17%
Pharmacology, Toxicology and Pharmaceutical Science 4 13%
Unspecified 4 13%
Chemistry 2 7%
Other 4 13%
Unknown 3 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2015.
All research outputs
#11,058,258
of 19,214,062 outputs
Outputs from Journal of Neuroinflammation
#1,216
of 2,274 outputs
Outputs of similar age
#102,930
of 225,837 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 1 outputs
Altmetric has tracked 19,214,062 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,274 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,837 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them