Title |
Clonal dissemination of linezolid-resistant Staphylococcus capitis with G2603T mutation in domain V of the 23S rRNA and the cfr gene at a tertiary care hospital in China
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Published in |
BMC Infectious Diseases, February 2015
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DOI | 10.1186/s12879-015-0841-z |
Pubmed ID | |
Authors |
Wanqing Zhou, Dongmei Niu, Xiaoli Cao, Mingzhe Ning, Zhifeng Zhang, Han Shen, Kui Zhang |
Abstract |
The present study aims to investigate the potential mechanism of linezolid-resistant Staphylococcus capitis (LRSC) isolates collected from our hospital. The susceptibilities of 5 Staphylococcus capitis isolates displaying resistance towards linezolid were determined by E-test. Polymerase chain reactions (PCRs) and DNA sequencing were used to investigate the potential molecular mechanism. Clonal relatedness between these strains was analyzed by pulsed-field gel electrophoresis (PFGE). The MICs of linezolid on these 5 isolates were >256 μg/mL. The G2603T mutation was observed in the domain V of the 23S rRNA with cfr gene being also widely detected among these 5 strains. PFGE analysis displayed close genetic relatedness between these linezolid-resistant isolates. The emergence of LRSC isolates carrying G2603T mutation in the domain V of the 23S rRNA and harboring cfr gene in our hospital may pose a potential challenge to the public health. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 32 | 100% |
Demographic breakdown
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Student > Master | 8 | 25% |
Student > Ph. D. Student | 5 | 16% |
Researcher | 3 | 9% |
Other | 2 | 6% |
Student > Bachelor | 2 | 6% |
Other | 4 | 13% |
Unknown | 8 | 25% |
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Immunology and Microbiology | 5 | 16% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Agricultural and Biological Sciences | 3 | 9% |
Environmental Science | 1 | 3% |
Other | 2 | 6% |
Unknown | 11 | 34% |