Title |
A cell-based high-throughput screening assay for radiation susceptibility using automated cell counting
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Published in |
Radiation Oncology, February 2015
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DOI | 10.1186/s13014-015-0355-2 |
Pubmed ID | |
Authors |
Jasmina Hodzic, Ilse Dingjan, Mariëlle JP Maas, Ida H van der Meulen-Muileman, Renee X de Menezes, Stan Heukelom, Marcel Verheij, Winald R Gerritsen, Albert A Geldof, Baukelien van Triest, Victor W van Beusechem |
Abstract |
Radiotherapy is one of the mainstays in the treatment for cancer, but its success can be limited due to inherent or acquired resistance. Mechanisms underlying radioresistance in various cancers are poorly understood and available radiosensitizers have shown only modest clinical benefit. There is thus a need to identify new targets and drugs for more effective sensitization of cancer cells to irradiation. Compound and RNA interference high-throughput screening technologies allow comprehensive enterprises to identify new agents and targets for radiosensitization. However, the gold standard assay to investigate radiosensitivity of cancer cells in vitro, the colony formation assay (CFA), is unsuitable for high-throughput screening. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 33% |
United States | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 28% |
Student > Master | 5 | 16% |
Professor > Associate Professor | 4 | 13% |
Student > Bachelor | 3 | 9% |
Other | 1 | 3% |
Other | 2 | 6% |
Unknown | 8 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 25% |
Medicine and Dentistry | 6 | 19% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Psychology | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 3 | 9% |
Unknown | 8 | 25% |