Title |
Human parainfluenza virus type 3 (HPIV3) induces production of IFNγ and RANTES in human nasal epithelial cells (HNECs)
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Published in |
Journal of Inflammation, February 2015
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DOI | 10.1186/s12950-015-0054-7 |
Pubmed ID | |
Authors |
Anna Lewandowska-Polak, Małgorzata Brauncajs, Edyta Paradowska, Marzanna Jarzębska, Marcin Kurowski, Sylwia Moskwa, Zbigniew J Leśnikowski, Marek L Kowalski |
Abstract |
Human parainfluenza virus type 3 (HPIV3), while infecting lower airway epithelial cells induces pneumonia and bronchiolitis in infants and children, and may lead to asthma exacerbations in children and adults. Respiratory viruses invading the airway epithelium activate innate immune response and induce inflammatory cytokine release contributing to the pathophysiology of upper and lower airway disorders. However, the effects of HPIV3 infection on nasal epithelial cells have not been well defined. The aim of this study was to evaluate the effect of the HPIV3 infection on cultured human nasal epithelial cells (HNECs) and the release of interferon gamma and other cytokines. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 28% |
Researcher | 4 | 10% |
Student > Bachelor | 3 | 8% |
Student > Master | 3 | 8% |
Other | 2 | 5% |
Other | 4 | 10% |
Unknown | 12 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 28% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Immunology and Microbiology | 4 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Environmental Science | 2 | 5% |
Other | 3 | 8% |
Unknown | 11 | 28% |