Title |
Septic encephalopathy: when cytokines interact with acetylcholine in the brain
|
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Published in |
Military Medical Research, September 2014
|
DOI | 10.1186/2054-9369-1-20 |
Pubmed ID | |
Authors |
Qing-Hong Zhang, Zhi-Yong Sheng, Yong-Ming Yao |
Abstract |
Sepsis-associated encephalopathy (SAE) is a brain dysfunction that occurs secondary to infection in the body, characterized by alteration of consciousness, ranging from delirium to coma, seizure or focal neurological signs. SAE involves a number of mechanisms, including neuroinflammation, in which the interaction between cytokines and acetylcholine results in neuronal loss and alterations in cholinergic signaling. Moreover, the interaction also occurs in the periphery, accelerating a type of immunosuppressive state. Although its diagnosis is not specific in biochemistry and imaging tests, it could potentiate severe outcomes, including increased mortality, cognitive decline, progressive immunosuppression, cholinergic anti-inflammatory deficiency, and even metabolic and hydroelectrolyte imbalance. Therefore, the bilateral communication between SAE and the multiple peripheral organs and especially the immune system should be emphasized in sepsis management. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 5 | 42% |
Oman | 1 | 8% |
Unknown | 6 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 75% |
Practitioners (doctors, other healthcare professionals) | 3 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 2% |
Unknown | 51 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 15% |
Researcher | 8 | 15% |
Student > Doctoral Student | 7 | 13% |
Student > Bachelor | 5 | 10% |
Student > Master | 4 | 8% |
Other | 13 | 25% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
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Neuroscience | 5 | 10% |
Agricultural and Biological Sciences | 4 | 8% |
Immunology and Microbiology | 2 | 4% |
Social Sciences | 1 | 2% |
Other | 2 | 4% |
Unknown | 7 | 13% |