Title |
Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation
|
---|---|
Published in |
Journal of Inflammation, February 2015
|
DOI | 10.1186/s12950-015-0060-9 |
Pubmed ID | |
Authors |
Monica de Gaetano, Kawthar Alghamdi, Simone Marcone, Orina Belton |
Abstract |
Atherosclerosis, the underlying cause of heart attack and strokes, is a progresive dyslipidemic and inflammatory disease where monocyte-derived macrophage cells play a pivotal role. Although most of the mechanisms that contribute to the progression of atherosclerosis have been identified, there is limited information on those governing regression. Conjugated linoleic acid (CLA) is a group of isomers of linoleic acid that differ in the position and/or geometry of their double bonds. We have previously shown that a specific CLA blend (80:20 cis-9,trans-11:trans-10,cis-12-CLA) induces regression of pre-established atherosclerosis in vivo, via modulation of monocyte/macrophage function. However, the exact mechanisms through which CLA mediates this effect remain to be elucidated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Ireland | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 20% |
Student > Master | 8 | 20% |
Student > Bachelor | 7 | 18% |
Student > Ph. D. Student | 7 | 18% |
Student > Doctoral Student | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 13% |
Agricultural and Biological Sciences | 5 | 13% |
Veterinary Science and Veterinary Medicine | 3 | 8% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Other | 7 | 18% |
Unknown | 11 | 28% |