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Starch and starch hydrolysates are favorable carbon sources for Bifidobacteria in the human gut

Overview of attention for article published in BMC Microbiology, March 2015
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  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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Title
Starch and starch hydrolysates are favorable carbon sources for Bifidobacteria in the human gut
Published in
BMC Microbiology, March 2015
DOI 10.1186/s12866-015-0362-3
Pubmed ID
Authors

Songling Liu, Fazheng Ren, Liang Zhao, Lu Jiang, Yanling Hao, Junhua Jin, Ming Zhang, Huiyuan Guo, Xingen Lei, Erna Sun, Hongna Liu

Abstract

Bifidobacteria are key commensals in human gut, and their abundance is associated with the health of their hosts. Although they are dominant in infant gut, their number becomes lower in adult gut. The changes of the diet are considered to be main reason for this difference. Large amounts of whole-genomic sequence data of bifidobacteria make it possible to elucidate the genetic interpretation of their adaptation to the nutrient environment. Among the nutrients in human gut, starch is a highly fermentable substrate and can exert beneficial effects by increasing bifidobacteria and/or being fermented to short chain fatty acids. In order to determine the potential substrate preference of bifidobacteria, we compared the glycoside hydrolase (GH) profiles of a pooled-bifidobacterial genome (PBG) with a representative microbiome (RM) of the human gut. In bifidobacterial genomes, only 15% of GHs contained signal peptides, suggesting their weakness in utilization of complex carbohydrate, such as plant cell wall polysaccharides. However, compared with other intestinal bacteria, bifidobacteiral genomes encoded more GH genes for degrading starch and starch hydrolysates, indicating that they have genetic advantages in utilizing these substrates. Bifidobacterium longum subsp. longum BBMN68 isolated from centenarian's faeces was used as a model strain to further investigate the carbohydrate utilization. The pathway for degrading starch and starch hydrolysates was the only complete pathway for complex carbohydrates in human gut. It is noteworthy that all of the GH genes for degrading starch and starch hydrolysates in the BBMN68 genome were conserved in all studied bifidobacterial strains. The in silico analyses of BBMN68 were further confirmed by growth experiments, proteomic and real-time quantitative PCR (RT-PCR) analyses. Our results demonstrated that starch and starch hydrolysates were the most universal and favorable carbon sources for bifidobacteria. The low amount of these carbon sources in adult intestine was speculated to contribute to the low relative abundance of bifidobacteria.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 1%
Unknown 92 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 18%
Researcher 17 18%
Student > Master 13 14%
Student > Bachelor 12 13%
Student > Doctoral Student 6 6%
Other 13 14%
Unknown 15 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 24%
Medicine and Dentistry 11 12%
Biochemistry, Genetics and Molecular Biology 9 10%
Immunology and Microbiology 8 9%
Engineering 5 5%
Other 14 15%
Unknown 24 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2021.
All research outputs
#6,143,881
of 22,793,427 outputs
Outputs from BMC Microbiology
#664
of 3,187 outputs
Outputs of similar age
#69,478
of 256,543 outputs
Outputs of similar age from BMC Microbiology
#13
of 66 outputs
Altmetric has tracked 22,793,427 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,187 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 256,543 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.