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Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock

Overview of attention for article published in Critical Care, December 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
9 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
50 Dimensions

Readers on

mendeley
60 Mendeley
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Title
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-0788-x
Pubmed ID
Authors

Erin L Vanzant, Rachael E Hilton, Cecilia M Lopez, Jianyi Zhang, Ricardo F Ungaro, Lori F Gentile, Benjamin E Szpila, Ronald V Maier, Joseph Cuschieri, Azra Bihorac, Christiaan Leeuwenburgh, Frederick A Moore, Henry V Baker, Lyle L Moldawer, Scott C Brakenridge, Philip A Efron

Abstract

We wished to characterize the relationship of advanced age to clinical outcomes and to transcriptomic responses after severe blunt traumatic injury with hemorrhagic shock. We performed epidemiological, cytokine, and transcriptomic analyses on a prospective, multi-center cohort of 1,928 severely injured patients. We found that there was no difference in injury severity between the aged (age ≥55, n = 533) and young (age <55, n = 1395) cohorts. However, aged patients had more comorbidities. Advanced age was associated with more severe organ failure, infectious complications, ventilator days, and intensive care unit length of stay, as well as, an increased likelihood of being discharged to skilled nursing or long-term care facilities. Additionally, advanced age was an independent predictor of a complicated recovery and 28-day mortality. Acutely after trauma, blood neutrophil genome-wide expression analysis revealed an attenuated transcriptomic response as compared to the young; this attenuated response was supported by the patients' plasma cytokine and chemokine concentrations. Later, these patients demonstrated gene expression changes consistent with simultaneous, persistent pro-inflammatory and immunosuppressive states. We concluded that advanced age is one of the strongest non-injury related risk factors for poor outcomes after severe trauma with hemorrhagic shock and is associated with an altered and unique peripheral leukocyte genomic response. As the general population's age increases, it will be important to individualize prediction models and therapeutic targets to this high risk cohort.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 59 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 22%
Other 9 15%
Student > Ph. D. Student 8 13%
Student > Master 7 12%
Student > Doctoral Student 4 7%
Other 7 12%
Unknown 12 20%
Readers by discipline Count As %
Medicine and Dentistry 26 43%
Nursing and Health Professions 6 10%
Biochemistry, Genetics and Molecular Biology 4 7%
Agricultural and Biological Sciences 4 7%
Engineering 2 3%
Other 4 7%
Unknown 14 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2015.
All research outputs
#4,777,110
of 18,042,414 outputs
Outputs from Critical Care
#2,877
of 5,413 outputs
Outputs of similar age
#57,481
of 223,902 outputs
Outputs of similar age from Critical Care
#11
of 35 outputs
Altmetric has tracked 18,042,414 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 5,413 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.0. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,902 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.