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Iron-dependent cell death as executioner of cancer stem cells

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, April 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

Mentioned by

patent
1 patent

Citations

dimensions_citation
22 Dimensions

Readers on

mendeley
15 Mendeley
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Title
Iron-dependent cell death as executioner of cancer stem cells
Published in
Journal of Experimental & Clinical Cancer Research, April 2018
DOI 10.1186/s13046-018-0733-3
Pubmed ID
Authors

Bin Zhao, Xin Li, Ye Wang, Peng Shang

Abstract

This commentary highlights the findings by Mai, et al. that ironomycin, derivatives of salinomycin, exhibited more potent and selective therapeutic activity against breast cancer stem cells by accumulating and sequestering iron in lysosome, followed by an iron-mediated lysosomal production of reactive oxygen species and an iron-dependent cell death. These unprecedented findings identified iron homeostasis and iron-mediated processes as potentially druggable in the context of cancer stem cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 20%
Lecturer 1 7%
Student > Bachelor 1 7%
Student > Doctoral Student 1 7%
Student > Ph. D. Student 1 7%
Other 1 7%
Unknown 7 47%
Readers by discipline Count As %
Medicine and Dentistry 3 20%
Chemistry 3 20%
Biochemistry, Genetics and Molecular Biology 2 13%
Psychology 1 7%
Unknown 6 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2022.
All research outputs
#8,538,940
of 25,382,440 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#574
of 2,382 outputs
Outputs of similar age
#138,991
of 343,274 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#16
of 39 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,382 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,274 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.