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The integrins

Overview of attention for article published in Genome Biology, June 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

blogs
2 blogs
patent
4 patents
wikipedia
4 Wikipedia pages

Citations

dimensions_citation
1015 Dimensions

Readers on

mendeley
1101 Mendeley
citeulike
7 CiteULike
connotea
1 Connotea
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Title
The integrins
Published in
Genome Biology, June 2007
DOI 10.1186/gb-2007-8-5-215
Pubmed ID
Authors

Yoshikazu Takada, Xiaojing Ye, Scott Simon

Abstract

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane alphabeta heterodimers and at least 18 alpha and eight beta subunits are known in humans, generating 24 heterodimers. Members of this family have been found in mammals, chicken and zebrafish, as well as lower eukaryotes, including sponges, the nematode Caenorhabditis elegans (two alpha and one beta subunits, generating two integrins) and the fruitfly Drosophila melanogaster (five alpha and one beta, generating five integrins). The alpha and beta subunits have distinct domain structures, with extracellular domains from each subunit contributing to the ligand-binding site of the heterodimer. The sequence arginine-glycine-aspartic acid (RGD) was identified as a general integrin-binding motif, but individual integrins are also specific for particular protein ligands. Immunologically important integrin ligands are the intercellular adhesion molecules (ICAMs), immunoglobulin superfamily members present on inflamed endothelium and antigen-presenting cells. On ligand binding, integrins transduce signals into the cell interior; they can also receive intracellular signals that regulate their ligand-binding affinity. Here we provide a brief overview that concentrates mostly on the organization, structure and function of mammalian integrins, which have been more extensively studied than integrins in other organisms.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 11 <1%
United Kingdom 9 <1%
Switzerland 2 <1%
Netherlands 2 <1%
Germany 2 <1%
Brazil 2 <1%
Belgium 2 <1%
India 1 <1%
Ireland 1 <1%
Other 9 <1%
Unknown 1060 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 292 27%
Student > Bachelor 154 14%
Student > Master 131 12%
Researcher 129 12%
Student > Doctoral Student 55 5%
Other 116 11%
Unknown 224 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 285 26%
Biochemistry, Genetics and Molecular Biology 236 21%
Medicine and Dentistry 97 9%
Engineering 40 4%
Chemistry 37 3%
Other 154 14%
Unknown 252 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2023.
All research outputs
#1,496,744
of 25,371,288 outputs
Outputs from Genome Biology
#1,198
of 4,467 outputs
Outputs of similar age
#2,814
of 83,004 outputs
Outputs of similar age from Genome Biology
#2
of 46 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 83,004 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.