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Sub-chronic toxicopathological study of lantadenes of Lantana camara weed in Guinea pigs

Overview of attention for article published in BMC Veterinary Research, April 2018
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Title
Sub-chronic toxicopathological study of lantadenes of Lantana camara weed in Guinea pigs
Published in
BMC Veterinary Research, April 2018
DOI 10.1186/s12917-018-1444-x
Pubmed ID
Authors

Rakesh Kumar, Rinku Sharma, Rajendra D. Patil, Gorakh Mal, Adarsh Kumar, Vikram Patial, Pawan Kumar, Bikram Singh

Abstract

In the field conditions, animals regularly consume small quantities of lantana leaves either while grazing or due to mixing with regular fodder. The hypothesis of this study was that consumption of lantana toxins over a long period of time leads to progression of sub-clinical disease. Toxicopathological effects of sub-chronic (90 days) administration of lantadenes of L. camara were investigated in guinea pigs. For this, a total of 40 animals were divided into 5 groups whereby groups I, II, III and IV were orally administered lantadenes, daily at the dose of 24, 18, 12, and 6 mg/kg bw, respectively while group V was control. The animals were evaluated by weekly body weight changes, haematology, serum liver and kidney markers, tissue oxidative markers and histopathology. The results of significant decrease in weekly body weights, haematology, liver and kidney marker enzymes (alanine aminotransaminase, aspartate aminotransaminase, acid phosphatase and creatinine), oxidation stress markers (lipid peroxidation, reduced glutathione, superoxide dismutase and catalase) in liver and kidneys, histopathology, and confirmation of fibrous collagenous tissue proliferation by Masson's Trichome stain showed that lantadenes led to a dose-dependent toxicity in decreasing order with the highest dose (24 mg/kg bw) producing maximum lesions and the lowest dose (6 mg/kg bw) producing minimum alterations. The study revealed that lantadenes which are considered to be classical hepatotoxicants in acute toxicity produced pronounced nephrotoxicity during sub-chronic exposure. Further studies are needed to quantify the levels of lantadenes in blood or serum of animals exposed to lantana in field conditions which would help to assess the extent of damage to the vital organs.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 33%
Researcher 3 17%
Student > Ph. D. Student 2 11%
Student > Master 2 11%
Student > Doctoral Student 1 6%
Other 1 6%
Unknown 3 17%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 5 28%
Pharmacology, Toxicology and Pharmaceutical Science 4 22%
Agricultural and Biological Sciences 2 11%
Medicine and Dentistry 2 11%
Economics, Econometrics and Finance 1 6%
Other 2 11%
Unknown 2 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2018.
All research outputs
#11,432,123
of 12,860,000 outputs
Outputs from BMC Veterinary Research
#1,478
of 1,828 outputs
Outputs of similar age
#194,799
of 223,855 outputs
Outputs of similar age from BMC Veterinary Research
#18
of 20 outputs
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.