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Zn2+ reverses functional deficits in a de novo dopamine transporter variant associated with autism spectrum disorder

Overview of attention for article published in Molecular Autism, February 2015
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Mentioned by

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1 tweeter
facebook
1 Facebook page

Citations

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18 Dimensions

Readers on

mendeley
42 Mendeley
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Title
Zn2+ reverses functional deficits in a de novo dopamine transporter variant associated with autism spectrum disorder
Published in
Molecular Autism, February 2015
DOI 10.1186/s13229-015-0002-7
Pubmed ID
Authors

Peter J Hamilton, Aparna Shekar, Andrea N Belovich, Nicole Bibus Christianson, Nicholas G Campbell, James S Sutcliffe, Aurelio Galli, Heinrich JG Matthies, Kevin Erreger

Abstract

Our laboratory recently characterized a novel autism spectrum disorder (ASD)-associated de novo missense mutation in the human dopamine transporter (hDAT) gene SLC6A3 (hDAT T356M). This hDAT variant exhibits dysfunctional forward and reverse transport properties that may contribute to DA dysfunction in ASD. Here, we report that Zn(2+) reverses, at least in part, the functional deficits of ASD-associated hDAT variant T356M. These data suggest that the molecular mechanism targeted by Zn(2+) to restore partial function in hDAT T356M may be a novel therapeutic target to rescue functional deficits in hDAT variants associated with ASD.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Colombia 1 2%
Unknown 39 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 29%
Student > Ph. D. Student 8 19%
Student > Bachelor 4 10%
Student > Master 4 10%
Student > Doctoral Student 3 7%
Other 5 12%
Unknown 6 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 19%
Biochemistry, Genetics and Molecular Biology 7 17%
Neuroscience 5 12%
Computer Science 3 7%
Psychology 3 7%
Other 8 19%
Unknown 8 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2015.
All research outputs
#10,174,980
of 13,330,958 outputs
Outputs from Molecular Autism
#389
of 422 outputs
Outputs of similar age
#136,159
of 215,516 outputs
Outputs of similar age from Molecular Autism
#2
of 2 outputs
Altmetric has tracked 13,330,958 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 422 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.9. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,516 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.