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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Metformin as a potential combination therapy with existing front-line antibiotics for Tuberculosis
|
|---|---|
| Published in |
Journal of Translational Medicine, January 2015
|
| DOI | 10.1186/s12967-015-0443-y |
| Pubmed ID | |
| Authors |
Rohit Vashisht, Samir K Brahmachari |
| Abstract |
Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb) remains a global health concern. The evolution of various multi-drug resistant strains through genetic mutations or drug tolerant strains through bacterial persistence renders existing antibiotics ineffective. Hence there is need for the development of either new antibiotics or rationalizing approved drugs that can be utilized in combination with existing antibiotics as a therapeutic strategy. A comprehensive systems level mapping of metabolic complexity in Mtb revels a putative role of NDH-I in the formation of bacterial persistence under the influence of front-line antibiotics. Possibilities of targeting bacterial NDH-I with existing FDA approved drug for type-II diabetes, Metformin, along with existing front-line antibiotics is discussed and proposed as a potential combination therapy for TB. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| India | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 76 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 23% |
| Student > Bachelor | 11 | 14% |
| Student > Ph. D. Student | 10 | 13% |
| Researcher | 7 | 9% |
| Student > Postgraduate | 5 | 6% |
| Other | 11 | 14% |
| Unknown | 17 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 27% |
| Agricultural and Biological Sciences | 11 | 14% |
| Biochemistry, Genetics and Molecular Biology | 8 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
| Nursing and Health Professions | 2 | 3% |
| Other | 11 | 14% |
| Unknown | 19 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2021.
All research outputs
#12,661,002
of 22,663,969 outputs
Outputs from Journal of Translational Medicine
#1,414
of 3,954 outputs
Outputs of similar age
#160,784
of 352,589 outputs
Outputs of similar age from Journal of Translational Medicine
#45
of 140 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,954 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,589 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.