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Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance

Overview of attention for article published in BMC Genomics, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

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1 blog
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7 X users

Citations

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39 Dimensions

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95 Mendeley
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Title
Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance
Published in
BMC Genomics, March 2015
DOI 10.1186/s12864-015-1358-y
Pubmed ID
Authors

Sho Maekawa, Naoto Imamachi, Takuma Irie, Hidenori Tani, Kyoko Matsumoto, Rena Mizutani, Katsutoshi Imamura, Miho Kakeda, Tetsushi Yada, Sumio Sugano, Yutaka Suzuki, Nobuyoshi Akimitsu

Abstract

Histone epigenome data determined by chromatin immunoprecipitation sequencing (ChIP-seq) is used in identifying transcript regions and estimating expression levels. However, this estimation does not always correlate with eventual RNA expression levels measured by RNA sequencing (RNA-seq). Part of the inconsistency may arise from the variance in RNA stability, where the transcripts that are more or less abundant than predicted RNA expression from histone epigenome data are inferred to be more or less stable. However, there is little systematic analysis to validate this assumption. Here, we used stability data of whole transcriptome measured by 5'-bromouridine immunoprecipitation chase sequencing (BRIC-seq), which enabled us to determine the half-lives of whole transcripts including lincRNAs, and we integrated BRIC-seq with ChIP-seq to achieve better estimation of the eventual transcript levels and to understand the importance of post-transcriptional regulation that determine the eventual transcript levels.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
Switzerland 1 1%
France 1 1%
Austria 1 1%
Argentina 1 1%
United States 1 1%
Unknown 89 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 34%
Researcher 18 19%
Student > Bachelor 7 7%
Professor > Associate Professor 5 5%
Student > Master 5 5%
Other 10 11%
Unknown 18 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 37 39%
Biochemistry, Genetics and Molecular Biology 28 29%
Medicine and Dentistry 9 9%
Computer Science 1 1%
Environmental Science 1 1%
Other 2 2%
Unknown 17 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2016.
All research outputs
#2,685,436
of 22,793,427 outputs
Outputs from BMC Genomics
#927
of 10,648 outputs
Outputs of similar age
#35,546
of 258,624 outputs
Outputs of similar age from BMC Genomics
#24
of 305 outputs
Altmetric has tracked 22,793,427 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,648 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,624 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 305 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.