Title |
An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome
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Published in |
Clinical Epigenetics, February 2015
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DOI | 10.1186/s13148-015-0048-6 |
Pubmed ID | |
Authors |
Omar Ali, Diana Cerjak, Jack W Kent, Roland James, John Blangero, Melanie A Carless, Yi Zhang |
Abstract |
The prevalence of chronic diseases such as cancer, type 2 diabetes, metabolic syndrome (MetS), and cardiovascular disease increases with age in all populations. Epigenetic features are hypothesized to play important roles in the pathophysiology of age-associated diseases, but a map of these markers is lacking. We searched for genome-wide age-associated methylation signatures in peripheral blood of individuals at high risks for MetS by profiling 485,000 CpG sites in 192 individuals of Northern European ancestry using the Illumina HM450 array. Subjects (ages 6-85 years) were part of seven extended families, and 73% of adults and 32% of children were overweight or obese. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 17% |
Unknown | 5 | 83% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
New Zealand | 1 | 2% |
Unknown | 57 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 21% |
Researcher | 10 | 17% |
Student > Bachelor | 7 | 12% |
Student > Master | 6 | 10% |
Student > Doctoral Student | 4 | 7% |
Other | 11 | 19% |
Unknown | 8 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 22% |
Medicine and Dentistry | 12 | 21% |
Agricultural and Biological Sciences | 7 | 12% |
Nursing and Health Professions | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 7 | 12% |
Unknown | 13 | 22% |