Title |
Hunk/Mak-v is a negative regulator of intestinal cell proliferation
|
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Published in |
BMC Cancer, March 2015
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DOI | 10.1186/s12885-015-1087-2 |
Pubmed ID | |
Authors |
Karen R Reed, Igor V Korobko, Natalia Ninkina, Elena V Korobko, Ben R Hopkins, James L Platt, Vladimir Buchman, Alan R Clarke |
Abstract |
Conditional deletion of the tumour suppressor gene Apc within the murine intestine results in acute Wnt signalling activation. The associated over-expression of a myriad of Wnt signalling target genes yields phenotypic alterations that encompass many of the hallmarks of neoplasia. Previous transcriptomic analysis aimed at identifying genes that potentially play an important role in this process, inferred the Hormonally upregulated Neu-associated kinase (HUNK/Mak-v/Bstk1) gene as a possible candidate. Hunk is a SNF1 (sucrose non fermenting 1)-related serine/threonine kinase with a proposed association with many different tumour types, including colorectal cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Australia | 1 | 17% |
United Kingdom | 1 | 17% |
Germany | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 25% |
Researcher | 4 | 20% |
Student > Ph. D. Student | 3 | 15% |
Professor | 2 | 10% |
Librarian | 1 | 5% |
Other | 2 | 10% |
Unknown | 3 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 55% |
Biochemistry, Genetics and Molecular Biology | 5 | 25% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Unknown | 3 | 15% |