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Therapeutic hypothermia after nonshockable cardiac arrest: the HYPERION multicenter, randomized, controlled, assessor-blinded, superiority trial

Overview of attention for article published in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, March 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)

Mentioned by

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56 tweeters
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1 Redditor

Citations

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91 Mendeley
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Title
Therapeutic hypothermia after nonshockable cardiac arrest: the HYPERION multicenter, randomized, controlled, assessor-blinded, superiority trial
Published in
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, March 2015
DOI 10.1186/s13049-015-0103-5
Pubmed ID
Authors

Jean Baptiste Lascarrou, Ferhat Meziani, Amélie Le Gouge, Thierry Boulain, Jérôme Bousser, Guillaume Belliard, Pierre Asfar, Jean Pierre Frat, Pierre François Dequin, Jean Paul Gouello, Arnaud Delahaye, Ali Ait Hssain, Jean Charles Chakarian, Nicolas Pichon, Arnaud Desachy, Fréderic Bellec, Didier Thevenin, Jean Pierre Quenot, Michel Sirodot, François Labadie, Gaétan Plantefeve, Dominique Vivier, Patrick Girardie, Bruno Giraudeau, Jean Reignier

Abstract

Meta-analyses of nonrandomized studies have provided conflicting data on therapeutic hypothermia, or targeted temperature management (TTM), at 33°C in patients successfully resuscitated after nonshockable cardiac arrest. Nevertheless, the latest recommendations issued by the International Liaison Committee on Resuscitation and by the European Resuscitation Council recommend therapeutic hypothermia. New data are available on the adverse effects of therapeutic hypothermia, notably infectious complications. The risk/benefit ratio of therapeutic hypothermia after nonshockable cardiac arrest is unclear. HYPERION is a multicenter (22 French ICUs) trial with blinded outcome assessment in which 584 patients with successfully resuscitated nonshockable cardiac arrest are allocated at random to either TTM between 32.5 and 33.5°C (therapeutic hypothermia) or TTM between 36.5 and 37.5°C (therapeutic normothermia) for 24 hours. Both groups are managed with therapeutic normothermia for the next 24 hours. TTM is achieved using locally available equipment. The primary outcome is day-90 neurological status assessed by the Cerebral Performance Categories (CPC) Scale with dichotomization of the results (1 + 2 versus 3 + 4 + 5). The primary outcome is assessed by a blinded psychologist during a semi-structured telephone interview of the patient or next of kin. Secondary outcomes are day-90 mortality, hospital mortality, severe adverse events, infections, and neurocognitive performance. The planned sample size of 584 patients will enable us to detect a 9% absolute difference in day-90 neurological status with 80% power, assuming a 14% event rate in the control group and a two-sided Type 1 error rate of 4.9%. Two interim analyses will be performed, after inclusion of 200 and 400 patients, respectively. The HYPERION trial is a multicenter, randomized, controlled, assessor-blinded, superiority trial that may provide an answer to an issue of everyday relevance, namely, whether TTM is beneficial in comatose patients resuscitated after nonshockable cardiac arrest. Furthermore, it will provide new data on the tolerance and adverse events (especially infectious complications) of TTM at 32.5-33.5°C. ClinicalTrials.gov: NCT01994772 .

Twitter Demographics

The data shown below were collected from the profiles of 56 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 1%
Unknown 90 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 15%
Other 11 12%
Researcher 11 12%
Student > Bachelor 8 9%
Student > Postgraduate 8 9%
Other 24 26%
Unknown 15 16%
Readers by discipline Count As %
Medicine and Dentistry 51 56%
Nursing and Health Professions 9 10%
Engineering 2 2%
Psychology 2 2%
Environmental Science 1 1%
Other 8 9%
Unknown 18 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2019.
All research outputs
#801,845
of 17,977,824 outputs
Outputs from Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#60
of 1,080 outputs
Outputs of similar age
#12,591
of 224,401 outputs
Outputs of similar age from Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#1
of 1 outputs
Altmetric has tracked 17,977,824 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,080 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,401 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them