Title |
Genome mining reveals unlocked bioactive potential of marine Gram-negative bacteria
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Published in |
BMC Genomics, March 2015
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DOI | 10.1186/s12864-015-1365-z |
Pubmed ID | |
Authors |
Henrique Machado, Eva C Sonnenschein, Jette Melchiorsen, Lone Gram |
Abstract |
Antibiotic resistance in bacteria spreads quickly, overtaking the pace at which new compounds are discovered and this emphasizes the immediate need to discover new compounds for control of infectious diseases. Terrestrial bacteria have for decades been investigated as a source of bioactive compounds leading to successful applications in pharmaceutical and biotech industries. Marine bacteria have so far not been exploited to the same extent; however, they are believed to harbor a multitude of novel bioactive chemistry. To explore this potential, genomes of 21 marine Alpha- and Gammaproteobacteria collected during the Galathea 3 expedition were sequenced and mined for natural product encoding gene clusters. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 14% |
Australia | 1 | 14% |
United Kingdom | 1 | 14% |
Spain | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 71% |
Scientists | 2 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 5 | 2% |
Spain | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 222 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 46 | 20% |
Researcher | 43 | 19% |
Student > Bachelor | 36 | 16% |
Student > Master | 29 | 13% |
Student > Postgraduate | 8 | 3% |
Other | 31 | 14% |
Unknown | 36 | 16% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 74 | 32% |
Biochemistry, Genetics and Molecular Biology | 51 | 22% |
Immunology and Microbiology | 17 | 7% |
Chemistry | 14 | 6% |
Environmental Science | 10 | 4% |
Other | 22 | 10% |
Unknown | 41 | 18% |