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The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice

Overview of attention for article published in Nutrition & Metabolism, March 2015
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Title
The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice
Published in
Nutrition & Metabolism, March 2015
DOI 10.1186/s12986-015-0003-8
Pubmed ID
Authors

Amit Kumar, Joseph Shiloach, Michael J Betenbaugh, Emily J Gallagher

Abstract

The hallmark of Type 2 diabetes (T2D) is hyperglycemia, although there are multiple other metabolic abnormalities that occur with T2D, including insulin resistance and dyslipidemia. To advance T2D prevention and develop targeted therapies for its treatment, a greater understanding of the alterations in metabolic tissues associated with T2D is necessary. The aim of this study was to use microarray analysis of gene expression in metabolic tissues from a mouse model of pre-diabetes and T2D to further understand the metabolic abnormalities that may contribute to T2D. We also aimed to uncover the novel genes and pathways regulated by the insulin sensitizing agent (CL-316,243) to identify key pathways and target genes in metabolic tissues that can reverse the diabetic phenotype.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 23%
Student > Bachelor 5 17%
Student > Ph. D. Student 5 17%
Other 2 7%
Student > Doctoral Student 2 7%
Other 4 13%
Unknown 5 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 23%
Biochemistry, Genetics and Molecular Biology 6 20%
Medicine and Dentistry 3 10%
Nursing and Health Professions 2 7%
Mathematics 1 3%
Other 4 13%
Unknown 7 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2015.
All research outputs
#18,402,666
of 22,794,367 outputs
Outputs from Nutrition & Metabolism
#773
of 947 outputs
Outputs of similar age
#188,508
of 258,838 outputs
Outputs of similar age from Nutrition & Metabolism
#7
of 9 outputs
Altmetric has tracked 22,794,367 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 947 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.3. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,838 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.