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Survival and digestibility of orally-administered immunoglobulin preparations containing IgG through the gastrointestinal tract in humans

Overview of attention for article published in Nutrition Journal, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
twitter
5 tweeters
googleplus
1 Google+ user

Citations

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63 Dimensions

Readers on

mendeley
160 Mendeley
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Title
Survival and digestibility of orally-administered immunoglobulin preparations containing IgG through the gastrointestinal tract in humans
Published in
Nutrition Journal, March 2015
DOI 10.1186/s12937-015-0010-7
Pubmed ID
Authors

Victoria S Jasion, Bruce P Burnett

Abstract

Oral immunoglobulin (Ig) preparations are prime examples of medicinal nutrition from natural sources. Plasma products containing Ig have been used for decades in animal feed for intestinal disorders to mitigate the damaging effects of early weaning. These preparations reduce overall mortality and increase feed utilization in various animal species leading to improved growth. Oral administration of Ig preparations from human serum as well as bovine colostrum and serum have been tested and proven to be safe as well as effective in human clinical trials for a variety of enteric microbial infections and other conditions which cause diarrhea. In infants, children, and adults, the amount of intact IgG recovered in stool ranges from trace amounts up to 25% of the original amount ingested. It is generally understood that IgG can only bind to antigens within the GI tract if the Fab structure is intact and has not been completely denatured through acidic pH or digestive proteolytic enzymes. This is a comprehensive review of human studies regarding the survivability of orally-administered Ig preparations, with a focus on IgG. This review also highlights various biochemical studies on IgG which potentially explain which structural elements are responsible for increased stability against digestion.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Mexico 1 <1%
France 1 <1%
Unknown 157 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 29 18%
Student > Ph. D. Student 20 13%
Student > Master 20 13%
Student > Bachelor 15 9%
Other 12 8%
Other 28 18%
Unknown 36 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 17%
Medicine and Dentistry 21 13%
Biochemistry, Genetics and Molecular Biology 20 13%
Pharmacology, Toxicology and Pharmaceutical Science 11 7%
Engineering 8 5%
Other 24 15%
Unknown 49 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2022.
All research outputs
#2,697,837
of 22,794,367 outputs
Outputs from Nutrition Journal
#587
of 1,427 outputs
Outputs of similar age
#35,589
of 258,823 outputs
Outputs of similar age from Nutrition Journal
#17
of 29 outputs
Altmetric has tracked 22,794,367 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,427 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.2. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,823 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.