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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Survival and digestibility of orally-administered immunoglobulin preparations containing IgG through the gastrointestinal tract in humans
|
|---|---|
| Published in |
Nutrition Journal, March 2015
|
| DOI | 10.1186/s12937-015-0010-7 |
| Pubmed ID | |
| Authors |
Victoria S Jasion, Bruce P Burnett |
| Abstract |
Oral immunoglobulin (Ig) preparations are prime examples of medicinal nutrition from natural sources. Plasma products containing Ig have been used for decades in animal feed for intestinal disorders to mitigate the damaging effects of early weaning. These preparations reduce overall mortality and increase feed utilization in various animal species leading to improved growth. Oral administration of Ig preparations from human serum as well as bovine colostrum and serum have been tested and proven to be safe as well as effective in human clinical trials for a variety of enteric microbial infections and other conditions which cause diarrhea. In infants, children, and adults, the amount of intact IgG recovered in stool ranges from trace amounts up to 25% of the original amount ingested. It is generally understood that IgG can only bind to antigens within the GI tract if the Fab structure is intact and has not been completely denatured through acidic pH or digestive proteolytic enzymes. This is a comprehensive review of human studies regarding the survivability of orally-administered Ig preparations, with a focus on IgG. This review also highlights various biochemical studies on IgG which potentially explain which structural elements are responsible for increased stability against digestion. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| United Kingdom | 1 | 17% |
| France | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Scientists | 1 | 17% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 172 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| France | 1 | <1% |
| Unknown | 169 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 18% |
| Student > Master | 24 | 14% |
| Student > Ph. D. Student | 21 | 12% |
| Student > Bachelor | 14 | 8% |
| Other | 12 | 7% |
| Other | 25 | 15% |
| Unknown | 45 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 17% |
| Medicine and Dentistry | 22 | 13% |
| Biochemistry, Genetics and Molecular Biology | 20 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 8% |
| Immunology and Microbiology | 7 | 4% |
| Other | 22 | 13% |
| Unknown | 59 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2023.
All research outputs
#2,534,599
of 23,332,901 outputs
Outputs from Nutrition Journal
#570
of 1,443 outputs
Outputs of similar age
#33,385
of 259,836 outputs
Outputs of similar age from Nutrition Journal
#17
of 29 outputs
Altmetric has tracked 23,332,901 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,443 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.7. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,836 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.