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Lactobacillus paracasei feeding improves the control of secondary experimental meningococcal infection in flu-infected mice

Overview of attention for article published in BMC Infectious Diseases, April 2018
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Title
Lactobacillus paracasei feeding improves the control of secondary experimental meningococcal infection in flu-infected mice
Published in
BMC Infectious Diseases, April 2018
DOI 10.1186/s12879-018-3086-9
Pubmed ID
Authors

Nouria Belkacem, Raphaëlle Bourdet-Sicard, Muhamed-Kkeir Taha

Abstract

The use of probiotics to improve anti-microbial defence, such as for influenza infections, is increasingly recommended. However, no data are available on the effect of probiotics on flu-associated secondary bacterial infections. There is strong evidence of a spatiotemporal association between influenza virus infection and invasive Neisseria meningitidis. We thus investigated the effect of feeding mice Lactobacillus paracasei CNCM I-1518 in a mouse model of sequential influenza-meningococcal infection. We intranasally infected BALB/c mice with a strain of influenza A virus (IAV) H3N2 that was first adapted to mice. Seven days later, a secondary bacterial infection was induced by intranasal administration of bioluminescent N. meningitidis. During the experiment, mice orally received either L. paracasei CNCM I-1518 or PBS as a control. The effect of L. paracasei administration on secondary bacterial infection by N. meningitidis was evaluated. Oral consumption of L. paracasei CNCM I-1518 reduced the weight loss of infected mice and lowered the bioluminescent signal of infecting meningococci. This improvement was associated with higher recruitment of inflammatory myeloid cells, such as interstitial monocytes and dendritic cells, to the lungs. Our data highlight the role of the gut-lung axis. L. paracasei CNCM I-1518 may boost the defence against IAV infection and secondary bacterial infection, which should be further studied and validated in clinical trials.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 13%
Student > Doctoral Student 3 9%
Other 2 6%
Unspecified 2 6%
Student > Bachelor 2 6%
Other 7 22%
Unknown 12 38%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 22%
Medicine and Dentistry 5 16%
Unspecified 2 6%
Biochemistry, Genetics and Molecular Biology 2 6%
Immunology and Microbiology 2 6%
Other 2 6%
Unknown 12 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2018.
All research outputs
#15,505,836
of 23,043,346 outputs
Outputs from BMC Infectious Diseases
#4,538
of 7,729 outputs
Outputs of similar age
#209,868
of 329,244 outputs
Outputs of similar age from BMC Infectious Diseases
#73
of 141 outputs
Altmetric has tracked 23,043,346 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,729 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,244 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 141 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.