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Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

Overview of attention for article published in Molecular Neurodegeneration, August 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
1 X user
patent
1 patent
wikipedia
1 Wikipedia page

Citations

dimensions_citation
197 Dimensions

Readers on

mendeley
216 Mendeley
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Title
Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
Published in
Molecular Neurodegeneration, August 2011
DOI 10.1186/1750-1326-6-60
Pubmed ID
Authors

Subbiah Pugazhenthi, Maorong Wang, Serena Pham, Chun-I Sze, Christopher B Eckman

Abstract

Oxidative stress plays an important role in neuronal dysfunction and neuron loss in Alzheimer's brain. Previous studies have reported downregulation of CREB-mediated transcription by oxidative stress and Aβ. The promoter for CREB itself contains cyclic AMP response elements. Therefore, we examined the expression of CREB in the hippocampal neurons of Tg2576 mice, AD post-mortem brain and in cultured rat hippocampal neurons exposed to Aβ aggregates.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 216 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 <1%
Canada 1 <1%
Germany 1 <1%
Belgium 1 <1%
United States 1 <1%
Unknown 210 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 52 24%
Student > Master 38 18%
Student > Bachelor 33 15%
Researcher 30 14%
Student > Doctoral Student 9 4%
Other 23 11%
Unknown 31 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 53 25%
Neuroscience 49 23%
Biochemistry, Genetics and Molecular Biology 22 10%
Medicine and Dentistry 18 8%
Pharmacology, Toxicology and Pharmaceutical Science 9 4%
Other 24 11%
Unknown 41 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2022.
All research outputs
#1,715,853
of 25,373,627 outputs
Outputs from Molecular Neurodegeneration
#161
of 977 outputs
Outputs of similar age
#7,820
of 134,179 outputs
Outputs of similar age from Molecular Neurodegeneration
#2
of 14 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 977 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 134,179 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.