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Alzheimer's disease: synapses gone cold

Overview of attention for article published in Molecular Neurodegeneration, August 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
1 news outlet
blogs
2 blogs
twitter
3 X users
patent
1 patent

Citations

dimensions_citation
247 Dimensions

Readers on

mendeley
375 Mendeley
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Title
Alzheimer's disease: synapses gone cold
Published in
Molecular Neurodegeneration, August 2011
DOI 10.1186/1750-1326-6-63
Pubmed ID
Authors

Robert M Koffie, Bradley T Hyman, Tara L Spires-Jones

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by insidious cognitive decline and memory dysfunction. Synapse loss is the best pathological correlate of cognitive decline in AD and mounting evidence suggests that AD is primarily a disease of synaptic dysfunction. Soluble oligomeric forms of amyloid beta (Aβ), the peptide that aggregates to form senile plaques in the brain of AD patients, have been shown to be toxic to neuronal synapses both in vitro and in vivo. Aβ oligomers inhibit long-term potentiation (LTP) and facilitate long-term depression (LTD), electrophysiological correlates of memory formation. Furthermore, oligomeric Aβ has also been shown to induce synapse loss and cognitive impairment in animals. The molecular underpinnings of these observations are now being elucidated, and may provide clear therapeutic targets for effectively treating the disease. Here, we review recent findings concerning AD pathogenesis with a particular focus on how Aβ impacts synapses.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 375 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 3 <1%
United Kingdom 2 <1%
United States 2 <1%
Australia 1 <1%
Germany 1 <1%
Peru 1 <1%
Portugal 1 <1%
Mexico 1 <1%
Canada 1 <1%
Other 0 0%
Unknown 362 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 86 23%
Researcher 51 14%
Student > Bachelor 49 13%
Student > Master 48 13%
Student > Doctoral Student 19 5%
Other 54 14%
Unknown 68 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 109 29%
Neuroscience 66 18%
Biochemistry, Genetics and Molecular Biology 40 11%
Medicine and Dentistry 38 10%
Pharmacology, Toxicology and Pharmaceutical Science 11 3%
Other 41 11%
Unknown 70 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2023.
All research outputs
#1,149,672
of 24,387,992 outputs
Outputs from Molecular Neurodegeneration
#63
of 910 outputs
Outputs of similar age
#4,802
of 127,375 outputs
Outputs of similar age from Molecular Neurodegeneration
#1
of 13 outputs
Altmetric has tracked 24,387,992 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 910 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,375 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.