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Molecular analysis of the effects of Piroxicam and Cisplatin on mesothelioma cells growth and viability

Overview of attention for article published in Journal of Translational Medicine, May 2008
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Mentioned by

peer_reviews
1 peer review site

Citations

dimensions_citation
18 Dimensions

Readers on

mendeley
8 Mendeley
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Title
Molecular analysis of the effects of Piroxicam and Cisplatin on mesothelioma cells growth and viability
Published in
Journal of Translational Medicine, May 2008
DOI 10.1186/1479-5876-6-27
Pubmed ID
Authors

Alessandra Verdina, Irene Cardillo, Angela Nebbioso, Rossella Galati, Simona Menegozzo, Lucia Altucci, Ada Sacchi, Alfonso Baldi

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been proposed for prevention and treatment of a variety of human cancers. Piroxicam, in particular, has been recently shown to exert significant anti-tumoral activity in combination with cisplatin (CDDP) on mesothelioma cells. However, the mechanisms through which NSAIDs regulate the cell cycle as well as the signal pathways involved in the growth inhibition, remain unclear. In the present study, using two mesothelioma cell lines, MSTO-211H and NCI-H2452, we have investigated the influence of piroxicam alone and in association with CDDP on proliferation, cell cycle regulation and apoptosis. In both cell lines a significant effect on cell growth inhibition, respect to the control, was observed with all the drugs tested. Moreover, treatment with piroxicam or CDDP alone altered the cell cycle phase distribution as well as the expression of some cell cycle regulatory proteins in both cell lines. These effects were increased, even if in a not completely overlapping manner, after treatment with the association of piroxicam and CDDP. In particular, the two drugs in NCI cell line had a synergistic effect on apoptosis, probably through activation of caspase 8 and caspase 9, while the most evident targets among the cell cycle regulators were cyclin D1 and p21waf1. These results suggest that the association of piroxicam and CDDP specifically triggers cell cycle regulation and apoptosis in different mesothelioma cell lines and may hold promise in the treatment of mesothelioma.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 13%
Student > Master 1 13%
Unknown 6 75%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 25%
Medicine and Dentistry 1 13%
Unknown 5 63%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 December 2016.
All research outputs
#4,771,947
of 8,817,966 outputs
Outputs from Journal of Translational Medicine
#1,099
of 1,912 outputs
Outputs of similar age
#110,416
of 204,876 outputs
Outputs of similar age from Journal of Translational Medicine
#69
of 106 outputs
Altmetric has tracked 8,817,966 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,912 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,876 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.