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Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma

Overview of attention for article published in BMC Cancer, December 2014
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Title
Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
Published in
BMC Cancer, December 2014
DOI 10.1186/1471-2407-14-978
Pubmed ID
Authors

Chong Hao, Peng-Xi Zhu, Xue Yang, Zhi-Peng Han, Jing-Hua Jiang, Chen Zong, Xu-Guang Zhang, Wen-Ting Liu, Qiu-Dong Zhao, Ting-Ting Fan, Li Zhang, Li-Xin Wei

Abstract

SIRT1 is a member of the mammalian sirtuin family with the ability to deacetylate histone and nonhistone proteins. The correlation between SIRT1 expression and tumor metastasis in several types of cancer has aroused widespread concern. This study investigated SIRT1 expression and its prognostic value in hepatocellular carcinoma (HCC). The function of SIRT1 in hepatocarcinogenesis was further investigated in cell culture and mouse models.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 17%
Student > Ph. D. Student 9 17%
Student > Bachelor 5 9%
Student > Master 5 9%
Student > Doctoral Student 4 7%
Other 9 17%
Unknown 13 24%
Readers by discipline Count As %
Medicine and Dentistry 12 22%
Agricultural and Biological Sciences 11 20%
Biochemistry, Genetics and Molecular Biology 8 15%
Immunology and Microbiology 3 6%
Engineering 2 4%
Other 2 4%
Unknown 16 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2015.
All research outputs
#17,750,476
of 22,794,367 outputs
Outputs from BMC Cancer
#4,955
of 8,295 outputs
Outputs of similar age
#242,198
of 353,402 outputs
Outputs of similar age from BMC Cancer
#100
of 163 outputs
Altmetric has tracked 22,794,367 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,295 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,402 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 163 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.