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The risk and predictors for severe radiation pneumonitis in lung cancer patients treated with thoracic reirradiation

Overview of attention for article published in Radiation Oncology, April 2018
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Title
The risk and predictors for severe radiation pneumonitis in lung cancer patients treated with thoracic reirradiation
Published in
Radiation Oncology, April 2018
DOI 10.1186/s13014-018-1016-z
Pubmed ID
Authors

Chengbo Ren, Tianlong Ji, Tingting Liu, Jun Dang, Guang Li

Abstract

Thoracic reirradiation (re-RT) is increasingly administered. However, radiation pneumonitis (RP) remains to be the most common side effect from retreatment. This study aimed to determine the risk and predictors for severe RP in patients receiving thoracic re-RT. Sixty seven patients with lung cancer received thoracic re-RT for recurrent or metastatic disease. Three-dimensional conformal radiotherapy (3D-CRT)/intensity modulated radiotherapy (IMRT) was used for 60 patients, and stereotactic body radiation therapy (SBRT) was used in 7 patients. Deformable image registration (DIR) was performed to create a composite plan. Severe (grade ≥ 3) RP was graded according to Common Terminology Criteria for Adverse Events version 4.0. Eighteen patients (26.9%) developed grade ≥ 3 RP (17 of grade 3, and 1 of grade 4). In univariate analyses, V5 and mean lung dose (MLD) of initial RT or re-RT plans, V5 and V20 of composite plans, and the overlap between V5 of initial RT and V5 of re-RT plans/V5 of re-RT plans (overlap-V5/re-V5) were significantly associated with grade ≥ 3 RP (P < 0.05 for each comparison). Multivariate analysis revealed that MLD of the initial RT plans (HR = 14.515, 95%CI:1.778-118.494, P = 0.013), V5 of the composite plans (HR = 7.398, 95%CI:1.319-41.495, P = 0.023), and overlap-V5/re-V5 (P = 0.041) were independent predictors for grade ≥ 3 RP. Out-of-field failures with medium overlap-V5/re-V5 of 0.4-0.8 was associated with higher risk of grade ≥ 3 RP compared with in-field failures (18.3% vs. 50%, P = 0.014). The risk of grade ≥ 3 RP could be predicted not only by dose-volume variables from re-RT plan, but also by some from initial-RT and composite plans. Out-of-field failures was associated with higher risk of severe RP compared with in-field failures in some cases.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 21%
Other 5 13%
Student > Ph. D. Student 5 13%
Student > Bachelor 3 8%
Professor > Associate Professor 3 8%
Other 5 13%
Unknown 9 24%
Readers by discipline Count As %
Medicine and Dentistry 16 42%
Physics and Astronomy 3 8%
Linguistics 1 3%
Nursing and Health Professions 1 3%
Psychology 1 3%
Other 2 5%
Unknown 14 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2018.
All research outputs
#14,035,677
of 15,917,147 outputs
Outputs from Radiation Oncology
#1,376
of 1,617 outputs
Outputs of similar age
#242,846
of 281,011 outputs
Outputs of similar age from Radiation Oncology
#1
of 1 outputs
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