Title |
Quality of life in patients with retinitis pigmentosa submitted to intravitreal use of bone marrow-derived stem cells (Reticell -clinical trial)
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Published in |
Stem Cell Research & Therapy, March 2015
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DOI | 10.1186/s13287-015-0020-6 |
Pubmed ID | |
Authors |
Rubens C Siqueira, Andre Messias, Katharina Messias, Rafael S Arcieri, Milton A Ruiz, Neiglene F Souza, Lia C Martins, Rodrigo Jorge |
Abstract |
Retinitis pigmentosa (RP) is a severe neurodegenerative disease of the retina that can lead to blindness. Even without treatment, a clinical study with the use of stem cells is currently underway and the results are being evaluated. In the present report we assess the vision-related quality of life in patients with RP submitted to intravitreal use of bone marrow-derived stem cells. The study included 20 patients with RP submitted to intravitreal use of bone marrow-derived stem cells. We evaluate the vision-related quality of life (VRQOL) of patients using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). Patients were scheduled to answer the questionnaire before treatment and 3 and 12 months after treatment. All patients completed the survey as scheduled. There was a statistically significant improvement (P <0.05) in the quality of life of patients 3 months after treatment, whereas by the 12th month there was no statistically significant difference from baseline. Cell therapy with intravitreal use of bone marrow-derived stem cells can improve the quality of life of patients with RP, although the improvement is lost with time. A larger number of cases will be necessary to evaluate the repercussions of this therapy on the quality of life of these patients. Clinicaltrials.gov: NCT01560715 . Registered March 19, 2012. |
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Unknown | 1 | 100% |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
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United States | 1 | <1% |
France | 1 | <1% |
Germany | 1 | <1% |
Unknown | 114 | 97% |
Demographic breakdown
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Researcher | 17 | 15% |
Student > Bachelor | 15 | 13% |
Other | 9 | 8% |
Student > Ph. D. Student | 8 | 7% |
Student > Postgraduate | 8 | 7% |
Other | 22 | 19% |
Unknown | 38 | 32% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 10 | 9% |
Neuroscience | 9 | 8% |
Agricultural and Biological Sciences | 9 | 8% |
Nursing and Health Professions | 5 | 4% |
Other | 15 | 13% |
Unknown | 42 | 36% |