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Retinoic acid-independent expression of Meis2 during autopod patterning in the developing bat and mouse limb

Overview of attention for article published in EvoDevo, March 2015
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Title
Retinoic acid-independent expression of Meis2 during autopod patterning in the developing bat and mouse limb
Published in
EvoDevo, March 2015
DOI 10.1186/s13227-015-0001-y
Pubmed ID
Authors

Mandy K Mason, Dorit Hockman, Lyle Curry, Thomas J Cunningham, Gregg Duester, Malcolm Logan, David S Jacobs, Nicola Illing

Abstract

The bat has strikingly divergent forelimbs (long digits supporting wing membranes) and hindlimbs (short, typically free digits) due to the distinct requirements of both aerial and terrestrial locomotion. During embryonic development, the morphology of the bat forelimb deviates dramatically from the mouse and chick, offering an alternative paradigm for identifying genes that play an important role in limb patterning. Using transcriptome analysis of developing Natal long-fingered bat (Miniopterus natalensis) fore- and hindlimbs, we demonstrate that the transcription factor Meis2 has a significantly higher expression in bat forelimb autopods compared to hindlimbs. Validation by reverse transcriptase and quantitative polymerase chain reaction (RT-qPCR) and whole mount in situ hybridisation shows that Meis2, conventionally known as a marker of the early proximal limb bud, is upregulated in the bat forelimb autopod from CS16. Meis2 expression is localised to the expanding interdigital webbing and the membranes linking the wing to the hindlimb and tail. In mice, Meis2 is also expressed in the interdigital region prior to tissue regression. This interdigital Meis2 expression is not activated by retinoic acid (RA) signalling as it is present in the retained interdigital tissue of Rdh10 (trex/trex) mice, which lack RA. Additionally, genes encoding RA-synthesising enzymes, Rdh10 and Aldh1a2, and the RA nuclear receptor Rarβ are robustly expressed in bat fore- and hindlimb interdigital tissues indicating that the mechanism that retains interdigital tissue in bats also occurs independently of RA signalling. Mammalian interdigital Meis2 expression, and upregulation in the interdigital webbing of bat wings, suggests an important role for Meis2 in autopod development. Interdigital Meis2 expression is RA-independent, and retention of interdigital webbing in bat wings is not due to the suppression of RA-induced cell death. Rather, RA signalling may play a role in the thinning (rather than complete loss) of the interdigital tissue in the bat forelimb, while Meis2 may interact with other factors during both bat and mouse autopod development to maintain a pool of interdigital cells that contribute to digit patterning and growth.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 3%
South Africa 2 3%
Germany 1 2%
Netherlands 1 2%
France 1 2%
Canada 1 2%
United States 1 2%
Unknown 50 85%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 22%
Student > Ph. D. Student 9 15%
Student > Bachelor 8 14%
Professor > Associate Professor 5 8%
Student > Postgraduate 4 7%
Other 5 8%
Unknown 15 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 49%
Biochemistry, Genetics and Molecular Biology 12 20%
Environmental Science 2 3%
Unknown 16 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2018.
All research outputs
#7,211,562
of 22,794,367 outputs
Outputs from EvoDevo
#182
of 318 outputs
Outputs of similar age
#85,348
of 261,657 outputs
Outputs of similar age from EvoDevo
#6
of 11 outputs
Altmetric has tracked 22,794,367 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 318 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,657 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.