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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cost effectiveness of option B plus for prevention of mother-to-child transmission of HIV in resource-limited countries: evidence from Kumasi, Ghana
|
|---|---|
| Published in |
BMC Infectious Diseases, March 2015
|
| DOI | 10.1186/s12879-015-0859-2 |
| Pubmed ID | |
| Authors |
Adam VanDeusen, Elijah Paintsil, Thomas Agyarko-Poku, Elisa F Long |
| Abstract |
Achieving the goal of eliminating mother-to-child HIV transmission (MTCT) necessitates increased access to antiretroviral therapy (ART) for HIV-infected pregnant women. Option B provides ART through pregnancy and breastfeeding, whereas Option B+ recommends continuous ART regardless of CD4 count, thus potentially reducing MTCT during future pregnancies. Our objective was to compare maternal and pediatric health outcomes and cost-effectiveness of Option B+ versus Option B in Ghana. A decision-analytic model was developed to simulate HIV progression in mothers and transmission (in utero, during birth, or through breastfeeding) to current and all future children. Clinical parameters, including antenatal care access and fertility rates, were estimated from a retrospective review of 817 medical records at two hospitals in Ghana. Additional parameters were obtained from published literature. Modeled outcomes include HIV infections averted among newborn children, quality-adjusted life-years (QALYs), and cost-effectiveness ratios. HIV-infected women in Ghana have a lifetime average of 2.3 children (SD 1.3). Projected maternal life expectancy under Option B+ is 16.1 years, versus 16.0 years with Option B, yielding a gain of 0.1 maternal QALYs and 3.2 additional QALYs per child. Despite higher initial ART costs, Option B+ costs $785/QALY gained, a value considered very cost-effective by World Health Organization benchmarks. Widespread implementation of Option B+ in Ghana could theoretically prevent up to 668 HIV infections among children annually. Cost-effectiveness estimates remained favorable over robust sensitivity analyses. Although more expensive than Option B, Option B+ substantially reduces MTCT in future pregnancies, increases both maternal and pediatric QALYs, and is a cost-effective use of limited resources in Ghana. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 222 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ethiopia | 1 | <1% |
| Ghana | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 219 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 51 | 23% |
| Researcher | 26 | 12% |
| Student > Ph. D. Student | 24 | 11% |
| Student > Bachelor | 18 | 8% |
| Student > Doctoral Student | 14 | 6% |
| Other | 42 | 19% |
| Unknown | 47 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 53 | 24% |
| Nursing and Health Professions | 40 | 18% |
| Social Sciences | 22 | 10% |
| Agricultural and Biological Sciences | 10 | 5% |
| Economics, Econometrics and Finance | 7 | 3% |
| Other | 31 | 14% |
| Unknown | 59 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2015.
All research outputs
#14,219,838
of 22,796,179 outputs
Outputs from BMC Infectious Diseases
#3,773
of 7,674 outputs
Outputs of similar age
#150,965
of 286,004 outputs
Outputs of similar age from BMC Infectious Diseases
#66
of 155 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,674 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,004 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 155 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.