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Mendeley readers
Attention Score in Context
| Title |
Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology
|
|---|---|
| Published in |
Journal of Neuroinflammation, February 2015
|
| DOI | 10.1186/s12974-015-0244-5 |
| Pubmed ID | |
| Authors |
Philip K-Y Chang, Armen Khatchadourian, Rebecca Anne McKinney, Dusica Maysinger |
| Abstract |
Recent studies have revealed that excessive activation of microglia and inflammation-mediated neurotoxicity are implicated in the progression of several neurological disorders. In particular, chronic inflammation in vivo and exposure of cultured brain cells to lipopolysaccharide (LPS) in vitro can adversely change microglial morphology and function. This can have both direct and indirect effects on synaptic structures and functions. The integrity of dendritic spines, the postsynaptic component of excitatory synapses, dictates synaptic efficacy. Interestingly, dysgenesis of dendritic spines has been found in many neurological diseases associated with ω-3 polyunsaturated fatty acid (PUFA) deficiency and cognitive decline. In contrast, supplemented ω-3 PUFAs, such as docosahexaenoic acid (DHA), can partly correct spine defects. Hence, we hypothesize that DHA directly affects synaptic integrity and indirectly through neuron-glia interaction. Strong activation of microglia by LPS is accompanied by marked release of nitric oxide and formation of lipid bodies (LBs), both dynamic biomarkers of inflammation. Here we investigated direct effects of DHA on synaptic integrity and its indirect effects via microglia in the hippocampal CA1 region. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 163 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Unknown | 162 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 22% |
| Researcher | 24 | 15% |
| Student > Master | 23 | 14% |
| Student > Bachelor | 22 | 13% |
| Student > Doctoral Student | 11 | 7% |
| Other | 18 | 11% |
| Unknown | 29 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 20% |
| Neuroscience | 31 | 19% |
| Biochemistry, Genetics and Molecular Biology | 20 | 12% |
| Medicine and Dentistry | 15 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 20 | 12% |
| Unknown | 38 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2023.
All research outputs
#14,488,946
of 25,202,494 outputs
Outputs from Journal of Neuroinflammation
#1,565
of 2,920 outputs
Outputs of similar age
#122,539
of 261,207 outputs
Outputs of similar age from Journal of Neuroinflammation
#20
of 43 outputs
Altmetric has tracked 25,202,494 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,920 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,207 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.