Title |
Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines
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Published in |
BMC Molecular and Cell Biology, April 2011
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DOI | 10.1186/1471-2091-12-15 |
Pubmed ID | |
Authors |
Monica Borgatti, Irene Mancini, Nicoletta Bianchi, Alessandra Guerrini, Ilaria Lampronti, Damiano Rossi, Gianni Sacchetti, Roberto Gambari |
Abstract |
Cystic fibrosis (CF) airway pathology is a fatal, autosomal, recessive genetic disease characterized by extensive lung inflammation. After induction by TNF-α, elevated concentrations of several pro-inflammatory cytokines (i.e. IL-6, IL-1β) and chemokines (i.e. IL-8) are released from airway epithelial cells. In order to reduce the excessive inflammatory response in the airways of CF patients, new therapies have been developed and in this respect, medicinal plant extracts have been studied. In this article we have investigated the possible use of bergamot extracts (Citrus bergamia Risso) and their identified components to alter the expression of IL-8 associated with the cystic fibrosis airway pathology. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 2% |
Unknown | 46 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 15% |
Professor > Associate Professor | 5 | 11% |
Student > Ph. D. Student | 5 | 11% |
Student > Bachelor | 5 | 11% |
Student > Master | 4 | 9% |
Other | 9 | 19% |
Unknown | 12 | 26% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 12 | 26% |
Chemistry | 6 | 13% |
Medicine and Dentistry | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 3 | 6% |
Unknown | 14 | 30% |