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EP2-PKA signaling is suppressed by triptolide in lipopolysaccharide-induced microglia activation

Overview of attention for article published in Journal of Neuroinflammation, March 2015
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Title
EP2-PKA signaling is suppressed by triptolide in lipopolysaccharide-induced microglia activation
Published in
Journal of Neuroinflammation, March 2015
DOI 10.1186/s12974-015-0275-y
Pubmed ID
Authors

Ting Zhang, Xiaoli Gong, Guanzheng Hu, Xiaomin Wang

Abstract

Microglia are key players for the inflammatory responses in the central nervous system. Suppression of microglial activation and the resulting production of proinflammatory molecules are considered a promising strategy to alleviate the progression of neurodegenerative disorders. Triptolide was demonstrated as a potent anti-inflammatory compound both in vitro and in vivo. The present study explored potential signal pathways of triptolide in the lipopolysaccharide (LPS)-induced inflammatory response using primary rat microglial cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 33%
Student > Master 3 17%
Professor 1 6%
Student > Doctoral Student 1 6%
Student > Bachelor 1 6%
Other 1 6%
Unknown 5 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 28%
Medicine and Dentistry 2 11%
Neuroscience 2 11%
Biochemistry, Genetics and Molecular Biology 1 6%
Chemical Engineering 1 6%
Other 2 11%
Unknown 5 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2016.
All research outputs
#5,571,396
of 7,367,723 outputs
Outputs from Journal of Neuroinflammation
#686
of 951 outputs
Outputs of similar age
#142,440
of 205,059 outputs
Outputs of similar age from Journal of Neuroinflammation
#25
of 32 outputs
Altmetric has tracked 7,367,723 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 951 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,059 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.