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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Adeno-associated virus type 2 infection activates caspase dependent and independent apoptosis in multiple breast cancer lines but not in normal mammary epithelial cells
|
|---|---|
| Published in |
Molecular Cancer, August 2011
|
| DOI | 10.1186/1476-4598-10-97 |
| Pubmed ID | |
| Authors |
Samina Alam, Brian S Bowser, Michael J Conway, Mohd Israr, Apurva Tandon, Craig Meyers |
| Abstract |
In normal cells proliferation and apoptosis are tightly regulated, whereas in tumor cells the balance is shifted in favor of increased proliferation and reduced apoptosis. Anticancer agents mediate tumor cell death via targeting multiple pathways of programmed cell death. We have reported that the non-pathogenic, tumor suppressive Adeno-Associated Virus Type 2 (AAV2) induces apoptosis in Human Papillomavirus (HPV) positive cervical cancer cells, but not in normal keratinocytes. In the current study, we examined the potential of AAV2 to inhibit proliferation of MCF-7 and MDA-MB-468 (both weakly invasive), as well as MDA-MB-231 (highly invasive) human breast cancer derived cell lines. As controls, we used normal human mammary epithelial cells (nHMECs) isolated from tissue biopsies of patients undergoing breast reduction surgery. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| Unknown | 53 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 31% |
| Researcher | 9 | 16% |
| Student > Master | 6 | 11% |
| Student > Bachelor | 4 | 7% |
| Professor > Associate Professor | 3 | 5% |
| Other | 7 | 13% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 35% |
| Medicine and Dentistry | 9 | 16% |
| Engineering | 5 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Neuroscience | 4 | 7% |
| Other | 6 | 11% |
| Unknown | 8 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2011.
All research outputs
#14,830,303
of 24,858,211 outputs
Outputs from Molecular Cancer
#960
of 1,870 outputs
Outputs of similar age
#82,541
of 124,796 outputs
Outputs of similar age from Molecular Cancer
#14
of 18 outputs
Altmetric has tracked 24,858,211 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,870 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 124,796 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.