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Adeno-associated virus type 2 infection activates caspase dependent and independent apoptosis in multiple breast cancer lines but not in normal mammary epithelial cells

Overview of attention for article published in Molecular Cancer, August 2011
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Mentioned by

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3 tweeters

Citations

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12 Dimensions

Readers on

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51 Mendeley
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Title
Adeno-associated virus type 2 infection activates caspase dependent and independent apoptosis in multiple breast cancer lines but not in normal mammary epithelial cells
Published in
Molecular Cancer, August 2011
DOI 10.1186/1476-4598-10-97
Pubmed ID
Authors

Samina Alam, Brian S Bowser, Michael J Conway, Mohd Israr, Apurva Tandon, Craig Meyers

Abstract

In normal cells proliferation and apoptosis are tightly regulated, whereas in tumor cells the balance is shifted in favor of increased proliferation and reduced apoptosis. Anticancer agents mediate tumor cell death via targeting multiple pathways of programmed cell death. We have reported that the non-pathogenic, tumor suppressive Adeno-Associated Virus Type 2 (AAV2) induces apoptosis in Human Papillomavirus (HPV) positive cervical cancer cells, but not in normal keratinocytes. In the current study, we examined the potential of AAV2 to inhibit proliferation of MCF-7 and MDA-MB-468 (both weakly invasive), as well as MDA-MB-231 (highly invasive) human breast cancer derived cell lines. As controls, we used normal human mammary epithelial cells (nHMECs) isolated from tissue biopsies of patients undergoing breast reduction surgery.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
Unknown 49 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 33%
Researcher 9 18%
Student > Master 6 12%
Student > Bachelor 4 8%
Professor > Associate Professor 3 6%
Other 7 14%
Unknown 5 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 37%
Medicine and Dentistry 9 18%
Engineering 5 10%
Biochemistry, Genetics and Molecular Biology 4 8%
Neuroscience 4 8%
Other 5 10%
Unknown 5 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2011.
All research outputs
#7,351,849
of 22,503,967 outputs
Outputs from Molecular Cancer
#531
of 1,701 outputs
Outputs of similar age
#38,643
of 107,796 outputs
Outputs of similar age from Molecular Cancer
#1
of 1 outputs
Altmetric has tracked 22,503,967 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,701 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,796 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them