Title |
Prevalence of pfhrp2 and pfhrp3 gene deletions in Puerto Lempira, Honduras
|
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Published in |
Malaria Journal, January 2015
|
DOI | 10.1186/s12936-014-0537-7 |
Pubmed ID | |
Authors |
Joseph F Abdallah, Sheila Akinyi Okoth, Gustavo A Fontecha, Rosa Elena Mejia Torres, Engels I Banegas, María Luisa Matute, Sandra Tamara Mancero Bucheli, Ira F Goldman, Alexandre Macedo de Oliveira, John W Barnwell, Venkatachalam Udhayakumar |
Abstract |
Recent studies have demonstrated the deletion of the histidine-rich protein 2 (PfHRP2) gene (pfhrp2) in field isolates of Plasmodium falciparum, which could result in false negative test results when PfHRP2-based rapid diagnostic tests (RDTs) are used for malaria diagnosis. Although primary diagnosis of malaria in Honduras is determined based on microscopy, RDTs may be useful in remote areas. In this study, it was investigated whether there are deletions of the pfhrp2, pfhrp3 and their respective flanking genes in 68 P. falciparum parasite isolates collected from the city of Puerto Lempira, Honduras. In addition, further investigation considered the possible correlation between parasite population structure and the distribution of these gene deletions by genotyping seven neutral microsatellites. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Unknown | 96 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 21 | 22% |
Student > Ph. D. Student | 16 | 16% |
Researcher | 15 | 15% |
Student > Bachelor | 6 | 6% |
Other | 4 | 4% |
Other | 12 | 12% |
Unknown | 23 | 24% |
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Other | 11 | 11% |
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