Title |
Feeding a high-grain diet reduces the percentage of LPS clearance and enhances immune gene expression in goat liver
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Published in |
BMC Veterinary Research, March 2015
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DOI | 10.1186/s12917-015-0376-y |
Pubmed ID | |
Authors |
Guangjun Chang, Kai Zhang, Tianle Xu, Di Jin, Hans-Martin Seyfert, Xiangzhen Shen, Su Zhuang |
Abstract |
The effects of feeding a high-grain (HG) diet on lipopolysaccharide (LPS) clearance and innate immune defence responses in the liver remain unclear. Therefore, we conducted the present study in which twelve female goats were randomly assigned to either a treatment group fed a HG diet (60% grain, n = 6) or a control group fed a low grain diet (LG; 40% grain, n = 6) for 6 weeks. Catheters were installed in the mesenteric, portal and hepatic veins, as well as one femoral artery of the goats, for determining blood flow and net clearance rate of LPS in the liver. Plasma and tissue samples were collected in the week 6 for analyzing pro-inflammatory cytokines, acute phase protein and biochemical parameters, as well as expression of genes involved in immune response. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 14% |
Professor > Associate Professor | 4 | 11% |
Student > Bachelor | 3 | 8% |
Student > Doctoral Student | 3 | 8% |
Researcher | 3 | 8% |
Other | 5 | 14% |
Unknown | 13 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 31% |
Veterinary Science and Veterinary Medicine | 3 | 8% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Medicine and Dentistry | 2 | 6% |
Other | 2 | 6% |
Unknown | 13 | 36% |