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No association of apolipoprotein B gene polymorphism and blood lipids in obese Egyptian subjects

Overview of attention for article published in Journal of Negative Results in BioMedicine, March 2015
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Title
No association of apolipoprotein B gene polymorphism and blood lipids in obese Egyptian subjects
Published in
Journal of Negative Results in BioMedicine, March 2015
DOI 10.1186/s12952-015-0026-8
Pubmed ID
Authors

Neda M Bogari, Azza M Abdel-Latif, Maha A Hassan, Abeer Ramadan, Ahmed Fawzy

Abstract

Several environmental and genetic factors are associated with high levels of lipids in obese patients. Apolipoprotein B (ApoB) is the major protein component of low-density lipoproteins (LDL), very-low density lipoproteins (VLDL) and chylomicrons and plays a central role in lipid metabolism. Several apoB restriction fragment length polymorphisms (XbaI, EcoRI, MspI) have been reported to be associated with variation in lipid levels and obesity. To date, no data are available on the relationship between XbaI polymorphism and lipid levels in Egyptian populations. Following clinical profiling, 178 obese (body mass index [BMI] >25 kg/m(2)) and 178 age-matched non-obese (BMI ≤ 25 kg/m2) subjects were included in this case-control study. All samples were analysed for total cholesterol, triglycerides and HDL-cholesterol. Genetic analysis of apoB XbaI (X) was performed using Polymerase Chain Reaction-Restriction Fragment Length polymorphism (PCR-RFLP). The aim of this study was to assess the association of apoB XbaI gene polymorphism (X) and lipid profiles in obese and non-obese Egyptian populations. Obese subjects demonstrated significantly higher values of waist-to-hip ratio, blood pressure, and total lipid. However, in our sample we did not find significant differences in apoB XbaI gene polymorphism (X) genotype or allele frequencies. Moreover, none of the studied lipid parameters showed any association with the gene polymorphism. This study reveals no significant association of apoB XbaI gene polymorphism (X) with obesity or lipid profiles in an Egyptian population.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 19%
Student > Master 5 16%
Student > Bachelor 4 13%
Student > Doctoral Student 2 6%
Student > Postgraduate 2 6%
Other 6 19%
Unknown 6 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 23%
Biochemistry, Genetics and Molecular Biology 5 16%
Medicine and Dentistry 5 16%
Nursing and Health Professions 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 2 6%
Unknown 10 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2015.
All research outputs
#17,751,741
of 22,796,179 outputs
Outputs from Journal of Negative Results in BioMedicine
#75
of 112 outputs
Outputs of similar age
#195,600
of 286,004 outputs
Outputs of similar age from Journal of Negative Results in BioMedicine
#4
of 5 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 112 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,004 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.