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High sensitivity C reactive protein, fibrinogen levels and the onset of major depressive disorder in post-acute coronary syndrome

Overview of attention for article published in BMC Cardiovascular Disorders, March 2015
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Title
High sensitivity C reactive protein, fibrinogen levels and the onset of major depressive disorder in post-acute coronary syndrome
Published in
BMC Cardiovascular Disorders, March 2015
DOI 10.1186/s12872-015-0015-3
Pubmed ID
Authors

Marianne Lafitte, Sandrine Tastet, Paul Perez, Marie-Aimée Serisé, Anne-Sophie Grandoulier, Bruno Aouizerate, Igor Sibon, Lucile Capuron, Thierry Couffinhal

Abstract

Major depression disorder (MDD) is a common condition in patients suffering from acute coronary syndrome (ACS), and depression is a risk factor for mortality following an ACS. Growing evidence suggests that there is an intricate interplay between atherosclerosis, inflammation and depression. The aim of this study was to investigate the role of atherosclerosis-induced inflammation in the mediation of MDD. 87 patients without depression were recruited at the time of an ACS, evaluated at 3 and 7 days and followed at 1, 3 and 9 months for the occurrence of a MDD as assessed by structured interviews (MINI). At each time point, they were monitored for inflammatory markers (high sensitivity C Reactive Protein {hsCRP} and fibrinogen), cardiovascular risk factors and atherosclerosis burden. Association between possible predictive characteristics and depression was assessed using a multivariable logistic regression model. The overall incidence of MDD, in this population, was 28.7% [95% CI: 19.5 - 39.4] during the 9-month follow up period. Elevated hsCRP was not associated with depression onset after an ACS (adjusted OR: 1.07 [0.77 - 1.48]; p = 0.70), and similarly no association was found with fibrinogen. Furthermore, we found no association between hsCRP, fibrinogen or atherosclerosis burden at any time-point, and the occurrence of a MDD (or HDRS-17 and MADRS). The only factor associated with depression occurrence after an ACS was a previous personal history of depression (adjusted OR: 11.02 [2.74 to 44.34]; p = 0.0007). The present study shows that after an ACS, patients treated with optimal medications could have a MDD independent of elevated hsCRP or fibrinogen levels. Personal history of depression may be a good marker to select patients who should be screened for depression after an ACS.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 20%
Researcher 8 18%
Student > Ph. D. Student 5 11%
Student > Bachelor 4 9%
Student > Doctoral Student 4 9%
Other 7 16%
Unknown 8 18%
Readers by discipline Count As %
Medicine and Dentistry 15 33%
Neuroscience 10 22%
Psychology 5 11%
Biochemistry, Genetics and Molecular Biology 2 4%
Agricultural and Biological Sciences 2 4%
Other 3 7%
Unknown 8 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2015.
All research outputs
#13,335,916
of 17,392,251 outputs
Outputs from BMC Cardiovascular Disorders
#739
of 1,139 outputs
Outputs of similar age
#149,381
of 228,026 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#1
of 1 outputs
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So far Altmetric has tracked 1,139 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
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