Title |
The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus
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Published in |
Clinical Epigenetics, March 2015
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DOI | 10.1186/s13148-015-0063-7 |
Pubmed ID | |
Authors |
Shuangyan Luo, Yu Liu, Gongping Liang, Ming Zhao, Haijing Wu, Yunsheng Liang, Xiangning Qiu, Yixin Tan, Yong Dai, Susan Yung, Tak-Mao Chan, Qianjin Lu |
Abstract |
The pathogenesis of systemic lupus erythematosus (SLE) has not yet been completely elucidated. One of the hallmarks of SLE is the production of autoantibodies by uncontrolled over-activated B cells. Early B cell factor 1 (EBF1) contributes to the development, activation, and proliferation of B cells through activation of the AKT signaling pathway. Accumulating evidence has demonstrated that several microRNAs (miRNAs) contribute to the pathogenesis of autoimmune diseases through the regulation of B cells in SLE. We aim to investigate the expression patterns of miR-1246 in B cells and its contribution to pathogenesis of SLE. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 26% |
Researcher | 7 | 15% |
Student > Postgraduate | 4 | 9% |
Student > Doctoral Student | 4 | 9% |
Student > Bachelor | 3 | 6% |
Other | 9 | 19% |
Unknown | 8 | 17% |
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Medicine and Dentistry | 8 | 17% |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 2 | 4% |
Unknown | 11 | 23% |