Title |
Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells
|
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Published in |
Molecular Cancer, September 2011
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DOI | 10.1186/1476-4598-10-117 |
Pubmed ID | |
Authors |
Mei Yang, Jingqi Chen, Fang Su, Bin Yu, Fengxi Su, Ling Lin, Yujie Liu, Jian-Dong Huang, Erwei Song |
Abstract |
Tumor-associated macrophages (TAMs) are alternatively activated cells induced by interleukin-4 (IL-4)-releasing CD4+ T cells. TAMs promote breast cancer invasion and metastasis; however, the mechanisms underlying these interactions between macrophages and tumor cells that lead to cancer metastasis remain elusive. Previous studies have found microRNAs (miRNAs) circulating in the peripheral blood and have identified microvesicles, or exosomes, as mediators of cell-cell communication. Therefore, one alternative mechanism for the promotion of breast cancer cell invasion by TAMs may be through macrophage-secreted exosomes, which would deliver invasion-potentiating miRNAs to breast cancer cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 1% |
United Kingdom | 4 | <1% |
Chile | 2 | <1% |
Germany | 2 | <1% |
Denmark | 2 | <1% |
Brazil | 2 | <1% |
Belgium | 2 | <1% |
Switzerland | 1 | <1% |
India | 1 | <1% |
Other | 10 | 2% |
Unknown | 468 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 133 | 27% |
Researcher | 107 | 21% |
Student > Master | 62 | 12% |
Student > Bachelor | 58 | 12% |
Professor > Associate Professor | 23 | 5% |
Other | 49 | 10% |
Unknown | 67 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 173 | 35% |
Biochemistry, Genetics and Molecular Biology | 95 | 19% |
Medicine and Dentistry | 71 | 14% |
Immunology and Microbiology | 17 | 3% |
Engineering | 16 | 3% |
Other | 47 | 9% |
Unknown | 80 | 16% |