Title |
Diabetes, cardiovascular disease and the microcirculation
|
---|---|
Published in |
Cardiovascular Diabetology, April 2018
|
DOI | 10.1186/s12933-018-0703-2 |
Pubmed ID | |
Authors |
W. David Strain, P. M. Paldánius |
Abstract |
Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for by conventional cardiovascular risk factors. Hypertension occurs in majority of people with T2DM, which is substantially more frequent than would be anticipated based on general population samples. The impact of hypertension is considerably higher in people with diabetes than it is in the general population, suggesting either an increased sensitivity to its effect or a confounding underlying aetiopathogenic mechanism of hypertension associated with CVD within diabetes. In this contribution, we aim to review the changes observed in the vascular tree in people with T2DM compared to the general population, the effects of established anti-diabetes drugs on microvascular outcomes, and explore the hypotheses to account for common causalities of the increased prevalence of CVD and hypertension in people with T2DM. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 13% |
Portugal | 1 | 13% |
Kenya | 1 | 13% |
India | 1 | 13% |
Spain | 1 | 13% |
Australia | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 50% |
Scientists | 2 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 642 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 101 | 16% |
Student > Master | 52 | 8% |
Student > Ph. D. Student | 45 | 7% |
Researcher | 36 | 6% |
Student > Doctoral Student | 34 | 5% |
Other | 94 | 15% |
Unknown | 280 | 44% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 149 | 23% |
Nursing and Health Professions | 42 | 7% |
Biochemistry, Genetics and Molecular Biology | 40 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 23 | 4% |
Agricultural and Biological Sciences | 16 | 2% |
Other | 66 | 10% |
Unknown | 306 | 48% |