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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ARP2/3 complex is required for directional migration of neural stem cell-derived oligodendrocyte precursors in electric fields
|
|---|---|
| Published in |
Stem Cell Research & Therapy, March 2015
|
| DOI | 10.1186/s13287-015-0042-0 |
| Pubmed ID | |
| Authors |
Yongchao Li, Pei-Shan Wang, George Lucas, Rong Li, Li Yao |
| Abstract |
The loss of oligodendrocytes in a lesion of the central nervous system causes demyelination and therefore impairs axon function and survival. Transplantation of neural stem cell (NSC)-derived oligodendrocyte precursor cells (OPCs) (NSC-OPCs) results in increased oligodendrocyte formation and enhanced remyelination. The directional migration of grafted cells to the target can promote the establishment of functional reconnection and myelination in the process of neural regeneration. Endogenous electric fields (EFs) that were detected in the development of the central nervous system can regulate cell migration. NSCs were isolated from the brains of ARPC2(+/+) and ARPC2(-/-) mouse embryo and differentiated into OPCs. After differentiation, the cultured oligospheres were stimulated with EFs (50mV/mm, 100mV/mm or 200mV/mm). The migration of OPCs from oligospheres were recorded using time-lapse microscopy. The cell migration directedness and speed were analyzed and quantified. In this study, we found that NSC-OPCs migrated toward the cathode pole in EFs. The directedness and displacement of cathodal migration increased significantly when the EF strength increased from 50 to 200 mV/mm. However, the EF did not significantly change the cell migration speed. We also showed that the migration speed of ARPC2(-/-) OPCs, deficient in the actin-related proteins 2 and 3 (ARP2/3) complex, was significantly lower than that of wild type of OPCs. ARPC2(-/-) OPCs migrated randomly in EFs. The migration direction of NSC-OPCs can be controlled by EFs. The function of ARP complex is required for the cathodal migration of NSC-OPCs in EFs. EF-guided cell migration is an effective model to understanding the intracellular signaling pathway in the regulation of cell migration directness and motility. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 39% |
| Researcher | 5 | 16% |
| Student > Bachelor | 5 | 16% |
| Student > Doctoral Student | 3 | 10% |
| Student > Master | 3 | 10% |
| Other | 2 | 6% |
| Unknown | 1 | 3% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 32% |
| Agricultural and Biological Sciences | 9 | 29% |
| Biochemistry, Genetics and Molecular Biology | 5 | 16% |
| Engineering | 3 | 10% |
| Medicine and Dentistry | 2 | 6% |
| Other | 1 | 3% |
| Unknown | 1 | 3% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2016.
All research outputs
#17,751,741
of 22,796,179 outputs
Outputs from Stem Cell Research & Therapy
#1,581
of 2,418 outputs
Outputs of similar age
#179,737
of 262,851 outputs
Outputs of similar age from Stem Cell Research & Therapy
#45
of 64 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,851 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.