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Adenosine triphosphate drives head and neck cancer pain through P2X2/3 heterotrimers

Overview of attention for article published in Acta Neuropathologica Communications, June 2014
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Title
Adenosine triphosphate drives head and neck cancer pain through P2X2/3 heterotrimers
Published in
Acta Neuropathologica Communications, June 2014
DOI 10.1186/2051-5960-2-62
Pubmed ID
Authors

Yi Ye, Kentaro Ono, Daniel G Bernabé, Chi T Viet, Victoria Pickering, John C Dolan, Markus Hardt, Anthony P Ford, Brian L Schmidt

Abstract

Cancer pain creates a poor quality of life and decreases survival. The basic neurobiology of cancer pain is poorly understood. Adenosine triphosphate (ATP) and the ATP ionotropic receptor subunits, P2X2 and P2X3, mediate cancer pain in animal models; however, it is unknown whether this mechanism operates in human, and if so, what the relative contribution of P2X2- and P2X3-containing trimeric channels to cancer pain is. Here, we studied head and neck squamous cell carcinoma (HNSCC), which causes the highest level of function-induced pain relative to other types of cancer.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 20%
Student > Master 7 17%
Student > Bachelor 5 12%
Student > Ph. D. Student 4 10%
Other 4 10%
Other 4 10%
Unknown 9 22%
Readers by discipline Count As %
Medicine and Dentistry 11 27%
Agricultural and Biological Sciences 7 17%
Biochemistry, Genetics and Molecular Biology 3 7%
Immunology and Microbiology 2 5%
Engineering 2 5%
Other 6 15%
Unknown 10 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2014.
All research outputs
#20,265,771
of 22,796,179 outputs
Outputs from Acta Neuropathologica Communications
#1,302
of 1,372 outputs
Outputs of similar age
#193,092
of 228,122 outputs
Outputs of similar age from Acta Neuropathologica Communications
#18
of 21 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,372 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,122 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.