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Mycoplasma iowae: relationships among oxygen, virulence, and protection from oxidative stress

Overview of attention for article published in Veterinary Research, January 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)

Mentioned by

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7 tweeters

Citations

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13 Dimensions

Readers on

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26 Mendeley
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Title
Mycoplasma iowae: relationships among oxygen, virulence, and protection from oxidative stress
Published in
Veterinary Research, January 2015
DOI 10.1186/s13567-015-0170-7
Pubmed ID
Authors

Rachel E Pritchard, Mitchell F Balish

Abstract

The poultry-associated bacterium Mycoplasma iowae colonizes multiple sites in embryos, with disease or death resulting. Although M. iowae accumulates in the intestinal tract, it does not cause disease at that site, but rather only in tissues that are exposed to atmospheric O2. The activity of M. iowae catalase, encoded by katE, is capable of rapid removal of damaging H2O2 from solution, and katE confers a substantial reduction in the amount of H2O2 produced by Mycoplasma gallisepticum katE transformants in the presence of glycerol. As catalase-producing bacteria are often beneficial to hosts with inflammatory bowel disease, we explored whether M. iowae was exclusively protective against H2O2-producing bacteria in a Caenorhabditis elegans model, whether its protectiveness changed in response to O2 levels, and whether expression of genes involved in H2O2 metabolism and virulence changed in response to O2 levels. We observed that M. iowae was in fact protective against H2O2-producing Streptococcus pneumoniae, but not HCN-producing Pseudomonas aeruginosa, and that M. iowae cells grown in 1% O2 promoted survival of C. elegans to a greater extent than M. iowae cells grown in atmospheric O2. Transcript levels of an M. iowae gene encoding a homolog of Mycoplasma pneumoniae CARDS toxin were 5-fold lower in cells grown in low O2. These data suggest that reduced O2, representing the intestinal environment, triggers M. iowae to reduce its virulence capabilities, effecting a change from a pathogenic mode to a potentially beneficial one.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 27%
Researcher 4 15%
Student > Master 3 12%
Student > Postgraduate 2 8%
Professor 1 4%
Other 3 12%
Unknown 6 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 19%
Biochemistry, Genetics and Molecular Biology 5 19%
Immunology and Microbiology 4 15%
Medicine and Dentistry 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Other 1 4%
Unknown 7 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2015.
All research outputs
#6,238,291
of 19,208,681 outputs
Outputs from Veterinary Research
#314
of 1,080 outputs
Outputs of similar age
#79,608
of 235,043 outputs
Outputs of similar age from Veterinary Research
#1
of 1 outputs
Altmetric has tracked 19,208,681 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,080 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,043 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them