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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Optogenetic regulation of transcription
|
|---|---|
| Published in |
BMC Neuroscience, April 2018
|
| DOI | 10.1186/s12868-018-0411-6 |
| Pubmed ID | |
| Authors |
Oksana Polesskaya, Ancha Baranova, Sarah Bui, Nikolai Kondratev, Evgeniya Kananykhina, Olga Nazarenko, Tatyana Shapiro, Frances Barg Nardia, Vladimir Kornienko, Vikas Chandhoke, Istvan Stadler, Raymond Lanzafame, Max Myakishev-Rempel |
| Abstract |
Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well known type of optogenetic constructs that employs photosensitive proteins to transduce the signal to regulate gene transcription, and its possible use in medicine. One of the problems with existing gene therapies is that they could remain active indefinitely while not allowing regulated transgene production on demand. Optogenetic regulation of transcription (ORT) could potentially be used to regulate the production of a biological drug in situ, by repeatedly applying light to the tissue, and inducing expression of therapeutic transgenes when needed. Red and near infrared wavelengths, which are capable of penetration into tissues, have potential for therapeutic applications. Existing ORT systems are reviewed herein with these considerations in mind. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 141 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 23% |
| Researcher | 21 | 15% |
| Student > Bachelor | 18 | 13% |
| Student > Master | 17 | 12% |
| Student > Postgraduate | 7 | 5% |
| Other | 18 | 13% |
| Unknown | 28 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 51 | 36% |
| Agricultural and Biological Sciences | 20 | 14% |
| Neuroscience | 10 | 7% |
| Chemistry | 7 | 5% |
| Engineering | 6 | 4% |
| Other | 12 | 9% |
| Unknown | 35 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2021.
All research outputs
#17,357,734
of 25,470,300 outputs
Outputs from BMC Neuroscience
#743
of 1,297 outputs
Outputs of similar age
#220,445
of 341,121 outputs
Outputs of similar age from BMC Neuroscience
#14
of 27 outputs
Altmetric has tracked 25,470,300 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,297 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,121 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.