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In vitro anti-proliferative activity of Argemone gracilenta and identification of some active components

Overview of attention for article published in BMC Complementary and Alternative Medicine, February 2015
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31 Mendeley
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Title
In vitro anti-proliferative activity of Argemone gracilenta and identification of some active components
Published in
BMC Complementary and Alternative Medicine, February 2015
DOI 10.1186/s12906-015-0532-8
Pubmed ID
Authors

Mario Alberto Leyva-Peralta, Ramón Enrique Robles-Zepeda, Adriana Garibay-Escobar, Eduardo Ruiz-Bustos, Laura Patricia Alvarez-Berber, Juan Carlos Gálvez-Ruiz

Abstract

BackgroundCancer is one of the leading causes of death worldwide. Natural products have been regarded as important sources of potential chemotherapeutic agents. In this study, we evaluated the anti-proliferative activity of Argemone gracilenta¿s methanol extract and its fractions. We identified those compounds of the most active fractions that displayed anti-proliferative activity.MethodsThe anti-proliferative activity on different cancerous cell lines (M12.C3F6, RAW 264.7, HeLa) was evaluated in vitro using the MTT colorimetric method. Identification of the active compounds present in the fractions with the highest activity was achieved by nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC-MS) analyses.ResultsBoth argemonine and berberine alkaloids, isolated from the ethyl acetate fraction, displayed high anti-proliferative activity with IC50 values of 2.8, 2.5, 12.1, and 2.7, 2.4, 79.5 ¿g/mL on M12.C3F6, RAW 264.7, and HeLa cancerous cell lines, respectively. No activity was shown on the normal L-929 cell line. From the hexane fraction, a mixture of fatty acids and fatty acid esters of 16 or more carbon atoms with anti-proliferative activity was identified, showing a range of IC50 values of 16.8-24.9, 34.1-35.4, and 67.6-91.8 ¿g/mL on M12.C3F6, RAW 264.7, and HeLa cancerous cell lines, respectively. On the normal L-929 cell line, this mixture showed a range of IC50 values of 85.1 to 100 ¿g/mL.ConclusionThis is the first study that relates argemonine, berberine, and a mixture of fatty acids and fatty acid esters with the anti-proliferative activity displayed by Argemone gracilenta.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 16%
Student > Bachelor 4 13%
Researcher 4 13%
Other 4 13%
Student > Ph. D. Student 4 13%
Other 4 13%
Unknown 6 19%
Readers by discipline Count As %
Medicine and Dentistry 5 16%
Agricultural and Biological Sciences 5 16%
Chemistry 4 13%
Biochemistry, Genetics and Molecular Biology 3 10%
Immunology and Microbiology 1 3%
Other 2 6%
Unknown 11 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2015.
All research outputs
#2,433,666
of 4,907,871 outputs
Outputs from BMC Complementary and Alternative Medicine
#813
of 1,543 outputs
Outputs of similar age
#76,198
of 145,366 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#38
of 60 outputs
Altmetric has tracked 4,907,871 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,543 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 145,366 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.