RT @zhaoweiasu: @GENBiotechJrnl @GrinsteinJ Regarding the RT error rate https://t.co/luDmp0Ce0C "Many DNA polymerases have a component call…
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@GrinsteinJ @GENBiotechJrnl You can take a look at my thread on this: https://t.co/ixKjabDdGk For autosomal recessive disease, correcting 50% of alleles by definition is a cure. For autosomal dominant disease, correcting 80~90% will be close to a cure. An
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@GENBiotechJrnl @GrinsteinJ Regarding the RT error rate https://t.co/luDmp0Ce0C "Many DNA polymerases have a component called “sliding clamps,” which resembles a donut" But then you need to find a way to load/unload the sliding clamps, which is typically a
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RT @davidrliu: @Biotech2k1 @GeneInvesting The error rate of prime editor RTs (similar to Superscript RT) are an insignificant source of mut…