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Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits

Overview of attention for article published in Molecular Neurodegeneration, April 2013
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211 Mendeley
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Title
Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits
Published in
Molecular Neurodegeneration, April 2013
DOI 10.1186/1750-1326-8-14
Pubmed ID
Authors

Miguel M Carvalho, Filipa L Campos, Bárbara Coimbra, José M Pêgo, Carla Rodrigues, Rui Lima, Ana J Rodrigues, Nuno Sousa, António J Salgado

Abstract

Parkinson's disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have focused on the emergence of non-motor symptoms in PD patients, as a consequence of damage on the mesolimbic and mesocortical dopaminergic networks, and on their significant impact on the quality of life of PD patients. Herein, we performed a thorough behavioral analysis including motor, emotional and cognitive dimensions, of the unilateral medial forebrain bundle (MFB) 6-hydroxidopamine (6-OHDA)-lesioned model of PD, and further addressed the impact of pharmacological interventions with levodopa and antidepressants on mood dimensions.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Chile 1 <1%
Spain 1 <1%
France 1 <1%
Unknown 207 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 16%
Student > Master 33 16%
Student > Bachelor 27 13%
Researcher 25 12%
Student > Doctoral Student 13 6%
Other 29 14%
Unknown 50 24%
Readers by discipline Count As %
Neuroscience 44 21%
Agricultural and Biological Sciences 37 18%
Medicine and Dentistry 22 10%
Pharmacology, Toxicology and Pharmaceutical Science 16 8%
Biochemistry, Genetics and Molecular Biology 12 6%
Other 19 9%
Unknown 61 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2013.
All research outputs
#20,265,771
of 22,796,179 outputs
Outputs from Molecular Neurodegeneration
#833
of 847 outputs
Outputs of similar age
#169,053
of 194,172 outputs
Outputs of similar age from Molecular Neurodegeneration
#6
of 6 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 847 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,172 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.