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Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits

Overview of attention for article published in Molecular Neurodegeneration, April 2013
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Citations

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178 Mendeley
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Title
Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits
Published in
Molecular Neurodegeneration, April 2013
DOI 10.1186/1750-1326-8-14
Pubmed ID
Authors

Miguel M Carvalho, Filipa L Campos, Bárbara Coimbra, José M Pêgo, Carla Rodrigues, Rui Lima, Ana J Rodrigues, Nuno Sousa, António J Salgado

Abstract

Parkinson's disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have focused on the emergence of non-motor symptoms in PD patients, as a consequence of damage on the mesolimbic and mesocortical dopaminergic networks, and on their significant impact on the quality of life of PD patients. Herein, we performed a thorough behavioral analysis including motor, emotional and cognitive dimensions, of the unilateral medial forebrain bundle (MFB) 6-hydroxidopamine (6-OHDA)-lesioned model of PD, and further addressed the impact of pharmacological interventions with levodopa and antidepressants on mood dimensions.

Mendeley readers

The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Chile 1 <1%
Spain 1 <1%
France 1 <1%
Unknown 174 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 17%
Student > Master 27 15%
Student > Bachelor 27 15%
Researcher 21 12%
Student > Doctoral Student 14 8%
Other 28 16%
Unknown 30 17%
Readers by discipline Count As %
Neuroscience 37 21%
Agricultural and Biological Sciences 33 19%
Medicine and Dentistry 21 12%
Pharmacology, Toxicology and Pharmaceutical Science 16 9%
Biochemistry, Genetics and Molecular Biology 10 6%
Other 18 10%
Unknown 43 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2013.
All research outputs
#2,897,646
of 3,634,284 outputs
Outputs from Molecular Neurodegeneration
#170
of 199 outputs
Outputs of similar age
#45,899
of 56,411 outputs
Outputs of similar age from Molecular Neurodegeneration
#3
of 5 outputs
Altmetric has tracked 3,634,284 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 199 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 56,411 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.