Title |
Immunotherapeutic approaches to ovarian cancer treatment
|
---|---|
Published in |
Journal for Immunotherapy of Cancer, March 2015
|
DOI | 10.1186/s40425-015-0051-7 |
Pubmed ID | |
Authors |
Cariad Chester, Oliver Dorigo, Jonathan S Berek, Holbrook Kohrt |
Abstract |
Despite advances in combinatorial chemotherapy regimens and the advent of intraperitoneal chemotherapy administration, current therapeutic options for ovarian cancer patients are inadequate. Immunotherapy offers a novel and promising therapeutic strategy for treating ovarian tumors. Following the demonstration of the immunogenicity of ovarian tumors, multiple immunotherapeutic modalities have been developed. Antibody-based therapies, immune checkpoint blockade, cancer vaccines, and chimeric antigen receptor-modified T cells have demonstrated preclinical success and entered clinical testing. In this review, we discuss these promising immunotherapeutic approaches and emphasize the importance of combinatorial treatment strategies and biomarker discovery. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Malaysia | 1 | <1% |
France | 1 | <1% |
Sweden | 1 | <1% |
India | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Denmark | 1 | <1% |
Korea, Republic of | 1 | <1% |
United States | 1 | <1% |
Unknown | 127 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 29 | 21% |
Student > Master | 22 | 16% |
Student > Bachelor | 17 | 13% |
Student > Ph. D. Student | 11 | 8% |
Student > Postgraduate | 11 | 8% |
Other | 17 | 13% |
Unknown | 28 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 30 | 22% |
Agricultural and Biological Sciences | 29 | 21% |
Biochemistry, Genetics and Molecular Biology | 17 | 13% |
Immunology and Microbiology | 12 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 13 | 10% |
Unknown | 29 | 21% |